A vascularis intervenciókat követo′ restenosis vizsgálata klinikai és kísérletes tanulmányokban

Translated title of the contribution: Restenosis following endovascular interventions: Clinical and experimental studies

Kristóf Hirschberg, L. Entz, G. Szabó, B. Merkely

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Restenosis following endovascular interventions is the main limitation of their long-term success. The incidence of restenosis varies according to the method (stenting, endarterectomy) and the treated vascular region, but the pathomechanism and risk factors are similar. The current article reviews of the author's previous studies in this field. In clinical studies, we compared the restenosis rate after carotid artery stenting and carotid endarterectomy. We also analyzed the complement activation profile after these interventions. In another study, we investigated the role of two polymorphisms of the estrogen receptor alpha in the occurrence of carotid restenosis after either carotid artery stenting or carotid endarterectomy. In an animal model of carotid endarterectomy, we studied the role of the nitrite-oxide-cyclic guanosine monophosphate signaling and the effect of the phosphodiesterase-5 inhibitor therapy in neointimal hyperplasia. Our results suggest that higher incidence of restenosis following carotid endarterectomy can be correlated with the more highly expressed complement activation after this type of carotid intervention. Polymorphisms in the estrogen receptor alpha gene could contribute to the restenosis formation, especially in women. Neointimal hyperplasia can be attenuated by increased cyclic guanosine monophosphate signaling.

Original languageHungarian
Pages (from-to)1307-1312
Number of pages6
JournalOrvosi Hetilap
Volume150
Issue number28
DOIs
Publication statusPublished - Jul 1 2009

Fingerprint

Carotid Endarterectomy
Estrogen Receptor alpha
Complement Activation
Cyclic GMP
Carotid Arteries
Hyperplasia
Phosphodiesterase 5 Inhibitors
Endarterectomy
Incidence
Nitrites
Oxides
Animal Models
Clinical Studies
Genes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A vascularis intervenciókat követo′ restenosis vizsgálata klinikai és kísérletes tanulmányokban. / Hirschberg, Kristóf; Entz, L.; Szabó, G.; Merkely, B.

In: Orvosi Hetilap, Vol. 150, No. 28, 01.07.2009, p. 1307-1312.

Research output: Contribution to journalArticle

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