Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness

E. T. Rolls, S. J. Thorpe, M. Boytim, I. Szabó, D. I. Perrett

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

In order to analyse the functions of dopamine, the effects of the iontophoretic application of dopamine on the responsiveness of striatal neurons to their normal inputs were investigated in the behaving monkey. It was shown that many neurons in the putamen had responses related to movements, of for example the mouth. Iontophoretically applied dopamine decreased the spontaneous firing rates of 178 of 267 neurons (67%) tested in the putamen, caudate nucleus, and the adjacent prefrontal cortex which also receives a dopaminergic projection. Trifluoperazine, applied iontophoretically to block dopamine receptors, increased the spontaneous firing rates of some of the neurons in the prefrontal cortex, suggesting that under normal conditions in the behaving animal the release of dopamine holds the firing rates of these neurons at a low level. The median was 9 spikes/s in the present sample of striatal neurons. Application of dopamine decreased the magnitude of the movement-related responses of the striatal neurons; this decrease in the responses was of approximately the same magnitude in spikes per second as the decrease in the spontaneous firing rate of the neurons produced by the same current of dopamine. It is suggested that this type of effect of dopamine could influence the signal to noise ratio of processing within the striatum, and that changes in this signal to noise ratio produced by disturbances of dopaminergic function could contribute to the behavioral disorders produced by dysfunctions of the dopaminergic systems.

Original languageEnglish
Pages (from-to)1201-1212
Number of pages12
JournalNeuroscience
Volume12
Issue number4
DOIs
Publication statusPublished - 1984

Fingerprint

Corpus Striatum
Haplorhini
Dopamine
Neurons
Putamen
Signal-To-Noise Ratio
Prefrontal Cortex
Trifluoperazine
Dopamine Agents
Caudate Nucleus
Dopamine Receptors
Mouth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness. / Rolls, E. T.; Thorpe, S. J.; Boytim, M.; Szabó, I.; Perrett, D. I.

In: Neuroscience, Vol. 12, No. 4, 1984, p. 1201-1212.

Research output: Contribution to journalArticle

Rolls, E. T. ; Thorpe, S. J. ; Boytim, M. ; Szabó, I. ; Perrett, D. I. / Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness. In: Neuroscience. 1984 ; Vol. 12, No. 4. pp. 1201-1212.
@article{00a06b73c4644af09bc2ced91add8319,
title = "Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness",
abstract = "In order to analyse the functions of dopamine, the effects of the iontophoretic application of dopamine on the responsiveness of striatal neurons to their normal inputs were investigated in the behaving monkey. It was shown that many neurons in the putamen had responses related to movements, of for example the mouth. Iontophoretically applied dopamine decreased the spontaneous firing rates of 178 of 267 neurons (67{\%}) tested in the putamen, caudate nucleus, and the adjacent prefrontal cortex which also receives a dopaminergic projection. Trifluoperazine, applied iontophoretically to block dopamine receptors, increased the spontaneous firing rates of some of the neurons in the prefrontal cortex, suggesting that under normal conditions in the behaving animal the release of dopamine holds the firing rates of these neurons at a low level. The median was 9 spikes/s in the present sample of striatal neurons. Application of dopamine decreased the magnitude of the movement-related responses of the striatal neurons; this decrease in the responses was of approximately the same magnitude in spikes per second as the decrease in the spontaneous firing rate of the neurons produced by the same current of dopamine. It is suggested that this type of effect of dopamine could influence the signal to noise ratio of processing within the striatum, and that changes in this signal to noise ratio produced by disturbances of dopaminergic function could contribute to the behavioral disorders produced by dysfunctions of the dopaminergic systems.",
author = "Rolls, {E. T.} and Thorpe, {S. J.} and M. Boytim and I. Szab{\'o} and Perrett, {D. I.}",
year = "1984",
doi = "10.1016/0306-4522(84)90014-9",
language = "English",
volume = "12",
pages = "1201--1212",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness

AU - Rolls, E. T.

AU - Thorpe, S. J.

AU - Boytim, M.

AU - Szabó, I.

AU - Perrett, D. I.

PY - 1984

Y1 - 1984

N2 - In order to analyse the functions of dopamine, the effects of the iontophoretic application of dopamine on the responsiveness of striatal neurons to their normal inputs were investigated in the behaving monkey. It was shown that many neurons in the putamen had responses related to movements, of for example the mouth. Iontophoretically applied dopamine decreased the spontaneous firing rates of 178 of 267 neurons (67%) tested in the putamen, caudate nucleus, and the adjacent prefrontal cortex which also receives a dopaminergic projection. Trifluoperazine, applied iontophoretically to block dopamine receptors, increased the spontaneous firing rates of some of the neurons in the prefrontal cortex, suggesting that under normal conditions in the behaving animal the release of dopamine holds the firing rates of these neurons at a low level. The median was 9 spikes/s in the present sample of striatal neurons. Application of dopamine decreased the magnitude of the movement-related responses of the striatal neurons; this decrease in the responses was of approximately the same magnitude in spikes per second as the decrease in the spontaneous firing rate of the neurons produced by the same current of dopamine. It is suggested that this type of effect of dopamine could influence the signal to noise ratio of processing within the striatum, and that changes in this signal to noise ratio produced by disturbances of dopaminergic function could contribute to the behavioral disorders produced by dysfunctions of the dopaminergic systems.

AB - In order to analyse the functions of dopamine, the effects of the iontophoretic application of dopamine on the responsiveness of striatal neurons to their normal inputs were investigated in the behaving monkey. It was shown that many neurons in the putamen had responses related to movements, of for example the mouth. Iontophoretically applied dopamine decreased the spontaneous firing rates of 178 of 267 neurons (67%) tested in the putamen, caudate nucleus, and the adjacent prefrontal cortex which also receives a dopaminergic projection. Trifluoperazine, applied iontophoretically to block dopamine receptors, increased the spontaneous firing rates of some of the neurons in the prefrontal cortex, suggesting that under normal conditions in the behaving animal the release of dopamine holds the firing rates of these neurons at a low level. The median was 9 spikes/s in the present sample of striatal neurons. Application of dopamine decreased the magnitude of the movement-related responses of the striatal neurons; this decrease in the responses was of approximately the same magnitude in spikes per second as the decrease in the spontaneous firing rate of the neurons produced by the same current of dopamine. It is suggested that this type of effect of dopamine could influence the signal to noise ratio of processing within the striatum, and that changes in this signal to noise ratio produced by disturbances of dopaminergic function could contribute to the behavioral disorders produced by dysfunctions of the dopaminergic systems.

UR - http://www.scopus.com/inward/record.url?scp=0021149158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021149158&partnerID=8YFLogxK

U2 - 10.1016/0306-4522(84)90014-9

DO - 10.1016/0306-4522(84)90014-9

M3 - Article

C2 - 6148716

AN - SCOPUS:0021149158

VL - 12

SP - 1201

EP - 1212

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 4

ER -