Responses of isolated rabbit common bile duct strips to field stimulation

E. Minker, E. Tamaskovits, T. Varkonyi

Research output: Contribution to journalArticle

Abstract

A special set-up was constructed for field stimulation of strips prepared from various portions of the common bile duct of the rabbit. Use of this apparatus revealed that in response to field stimulation the sphincteric region produced spontaneous movements and reactivity, whereas the median and hepatic portions exhibited weak irregular reactivity, but not spontaneous movements. Field stimulation of the sphincteric portion with optimized impulse parameters produced contraction, then relaxation and cessation of the spontaneous movements. The effects of field stimulation were inhibited to different extent by beta adrenergic blockers (oxprenolol and propranolol), calcium channel blockers (verapamil, fendiline and nifedipine), atropine, papaverine, bencyclane and methadone. The effects of field stimulation was not influenced by morphine. Pethidine had no effect on the sphincteric portion, but contracted the median and hepatic portions, increasing ((the effects of field stimulation in a dose-dependent manner.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalActa pharmaceutica Hungarica
Volume64
Issue number6
Publication statusPublished - Jan 1 1994

ASJC Scopus subject areas

  • Pharmaceutical Science

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