Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy

A. Zoubek, P. Kajtar, B. Flucher-Wolfram, B. Holzinger, G. Mostbeck, L. Thun- Hohenstein, F. M. Fink, C. Urban, I. Mutz, D. Schuler, H. Gadner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A total of nine children with previously untreated stage IV Wilms' tumor of favorable histology were treated according to the Austrian/Hungarian Wilms' Tumor Protocol 89 and received a preoperative single dose of carboplatin as an 'up front' window therapy. The treatment consisted of carboplatin as a single-dose of 600 mg/m2 over 30 minutes on day 1. Response evaluation by chest X-ray, serial CT scans, and sonography was performed on day 22. Investigation of the abdominal tumors revealed seven partial responses (78%), one nonresponse, and one progressive disease with a median tumor volume reduction of 62%. Response of metastases evaluated by CT scans was as follows: four complete remission, four partial response, and one nonresponse. Thrombocytopenia (WHO grade III 1, grade II 2, grade I 2) and leukocytopenia (WHO grade II 1, grade I 5) were the main side effects. No renal or liver toxicity were observed. The overall response rate after a preoperative single-dose of 600 mg/m2 carboplatin in untreated patients with stage IV Wilms' tumor is encouraging and the toxicity acceptable. This data indicate that carboplatin seems to be an additional effective drug in patients with previously untreated Wilms' tumor of favorable histology.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalMedical and Pediatric Oncology
Volume25
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Wilms Tumor
Carboplatin
Histology
X Ray Computed Tomography
Leukopenia
Therapeutics
Tumor Burden
Thrombocytopenia
Ultrasonography
Thorax
Neoplasm Metastasis
Kidney
Liver
Pharmaceutical Preparations
Neoplasms

Keywords

  • carboplatin (CBDCA)
  • nephroblastoma
  • preoperative chemotherapy
  • Wilms' tumor stage IV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Zoubek, A., Kajtar, P., Flucher-Wolfram, B., Holzinger, B., Mostbeck, G., Thun- Hohenstein, L., ... Gadner, H. (1995). Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy. Medical and Pediatric Oncology, 25(1), 8-11. https://doi.org/10.1002/mpo.2950250103

Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy. / Zoubek, A.; Kajtar, P.; Flucher-Wolfram, B.; Holzinger, B.; Mostbeck, G.; Thun- Hohenstein, L.; Fink, F. M.; Urban, C.; Mutz, I.; Schuler, D.; Gadner, H.

In: Medical and Pediatric Oncology, Vol. 25, No. 1, 1995, p. 8-11.

Research output: Contribution to journalArticle

Zoubek, A, Kajtar, P, Flucher-Wolfram, B, Holzinger, B, Mostbeck, G, Thun- Hohenstein, L, Fink, FM, Urban, C, Mutz, I, Schuler, D & Gadner, H 1995, 'Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy', Medical and Pediatric Oncology, vol. 25, no. 1, pp. 8-11. https://doi.org/10.1002/mpo.2950250103
Zoubek, A. ; Kajtar, P. ; Flucher-Wolfram, B. ; Holzinger, B. ; Mostbeck, G. ; Thun- Hohenstein, L. ; Fink, F. M. ; Urban, C. ; Mutz, I. ; Schuler, D. ; Gadner, H. / Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy. In: Medical and Pediatric Oncology. 1995 ; Vol. 25, No. 1. pp. 8-11.
@article{cfe58dd0e5b7450aa05ffb2302fbb925,
title = "Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy",
abstract = "A total of nine children with previously untreated stage IV Wilms' tumor of favorable histology were treated according to the Austrian/Hungarian Wilms' Tumor Protocol 89 and received a preoperative single dose of carboplatin as an 'up front' window therapy. The treatment consisted of carboplatin as a single-dose of 600 mg/m2 over 30 minutes on day 1. Response evaluation by chest X-ray, serial CT scans, and sonography was performed on day 22. Investigation of the abdominal tumors revealed seven partial responses (78{\%}), one nonresponse, and one progressive disease with a median tumor volume reduction of 62{\%}. Response of metastases evaluated by CT scans was as follows: four complete remission, four partial response, and one nonresponse. Thrombocytopenia (WHO grade III 1, grade II 2, grade I 2) and leukocytopenia (WHO grade II 1, grade I 5) were the main side effects. No renal or liver toxicity were observed. The overall response rate after a preoperative single-dose of 600 mg/m2 carboplatin in untreated patients with stage IV Wilms' tumor is encouraging and the toxicity acceptable. This data indicate that carboplatin seems to be an additional effective drug in patients with previously untreated Wilms' tumor of favorable histology.",
keywords = "carboplatin (CBDCA), nephroblastoma, preoperative chemotherapy, Wilms' tumor stage IV",
author = "A. Zoubek and P. Kajtar and B. Flucher-Wolfram and B. Holzinger and G. Mostbeck and {Thun- Hohenstein}, L. and Fink, {F. M.} and C. Urban and I. Mutz and D. Schuler and H. Gadner",
year = "1995",
doi = "10.1002/mpo.2950250103",
language = "English",
volume = "25",
pages = "8--11",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by 'up front' window therapy

AU - Zoubek, A.

AU - Kajtar, P.

AU - Flucher-Wolfram, B.

AU - Holzinger, B.

AU - Mostbeck, G.

AU - Thun- Hohenstein, L.

AU - Fink, F. M.

AU - Urban, C.

AU - Mutz, I.

AU - Schuler, D.

AU - Gadner, H.

PY - 1995

Y1 - 1995

N2 - A total of nine children with previously untreated stage IV Wilms' tumor of favorable histology were treated according to the Austrian/Hungarian Wilms' Tumor Protocol 89 and received a preoperative single dose of carboplatin as an 'up front' window therapy. The treatment consisted of carboplatin as a single-dose of 600 mg/m2 over 30 minutes on day 1. Response evaluation by chest X-ray, serial CT scans, and sonography was performed on day 22. Investigation of the abdominal tumors revealed seven partial responses (78%), one nonresponse, and one progressive disease with a median tumor volume reduction of 62%. Response of metastases evaluated by CT scans was as follows: four complete remission, four partial response, and one nonresponse. Thrombocytopenia (WHO grade III 1, grade II 2, grade I 2) and leukocytopenia (WHO grade II 1, grade I 5) were the main side effects. No renal or liver toxicity were observed. The overall response rate after a preoperative single-dose of 600 mg/m2 carboplatin in untreated patients with stage IV Wilms' tumor is encouraging and the toxicity acceptable. This data indicate that carboplatin seems to be an additional effective drug in patients with previously untreated Wilms' tumor of favorable histology.

AB - A total of nine children with previously untreated stage IV Wilms' tumor of favorable histology were treated according to the Austrian/Hungarian Wilms' Tumor Protocol 89 and received a preoperative single dose of carboplatin as an 'up front' window therapy. The treatment consisted of carboplatin as a single-dose of 600 mg/m2 over 30 minutes on day 1. Response evaluation by chest X-ray, serial CT scans, and sonography was performed on day 22. Investigation of the abdominal tumors revealed seven partial responses (78%), one nonresponse, and one progressive disease with a median tumor volume reduction of 62%. Response of metastases evaluated by CT scans was as follows: four complete remission, four partial response, and one nonresponse. Thrombocytopenia (WHO grade III 1, grade II 2, grade I 2) and leukocytopenia (WHO grade II 1, grade I 5) were the main side effects. No renal or liver toxicity were observed. The overall response rate after a preoperative single-dose of 600 mg/m2 carboplatin in untreated patients with stage IV Wilms' tumor is encouraging and the toxicity acceptable. This data indicate that carboplatin seems to be an additional effective drug in patients with previously untreated Wilms' tumor of favorable histology.

KW - carboplatin (CBDCA)

KW - nephroblastoma

KW - preoperative chemotherapy

KW - Wilms' tumor stage IV

UR - http://www.scopus.com/inward/record.url?scp=0029071708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029071708&partnerID=8YFLogxK

U2 - 10.1002/mpo.2950250103

DO - 10.1002/mpo.2950250103

M3 - Article

VL - 25

SP - 8

EP - 11

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 1

ER -