Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats

Jana Bundzikova, Zdeno Pirnik, D. Zelena, Jens D. Mikkelsen, Alexander Kiss

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The intention of this review is to emphasize the current knowledge about the extent and importance of the substances co-localized with magnocellular arginine vasopressin (AVP) and oxytocin (OXY) as potential candidates for the gradual clarification of their actual role in the regulation of hydromineral homeostasis. Maintenance of the body hydromineral balance depends on the coordinated action of principal biologically active compounds, AVP and OXY, synthesized in the hypothalamic supraoptic and paraventricular nuclei. However, on the regulation of water-salt balance, other substances, co-localized with the principal neuropetides, participate. These can be classified as (1) peptides co-localized with AVP or OXY with unambiguous osmotic function, including angiotensin II, apelin, corticotropin releasing hormone, and galanin and (2) peptides co-localized with AVP or OXY with an unknown role in osmotic regulation, including cholecystokinin, chromogranin/secretogranin, dynorphin, endothelin-1, enkephalin, ferritin protein, interleukin 6, kininogen, neurokinin B, neuropeptide Y, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, TAFA5 protein, thyrotropin releasing hormone, tyrosine hydroxylase, and urocortin. In this brief review, also the responses of these substances to different hyperosmotic and hypoosmotic challenges are pointed out. Based on the literature data published recently, the functional implication of the majority of co-localized substances is still better understood in non-osmotic than osmotic functional circuits. Brattleboro strain of rats that does not express functional vasopressin was also included in this review. These animals suffer from chronic hypernatremia and hyperosmolality, accompanied by sustained increase in OXY mRNA in PVN and SON and OXY levels in plasma. They represent an important model of animals with constantly sustained osmolality, which in the future, will be utilizable for revealing the physiological importance of biologically active substances co-expressed with AVP and OXY, involved in the regulation of plasma osmolality.

Original languageEnglish
Pages (from-to)1033-1047
Number of pages15
JournalCellular and Molecular Neurobiology
Volume28
Issue number8
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Brattleboro Rats
Vasotocin
Arginine Vasopressin
Neurons
Chromogranins
Oxytocin
Osmolar Concentration
Neurokinin B
Urocortins
Kininogens
Hypernatremia
Pituitary Adenylate Cyclase-Activating Polypeptide
Galanin
Dynorphins
Supraoptic Nucleus
Peptides
Thyrotropin-Releasing Hormone
Enkephalins
Neuropeptide Y
Corticotropin-Releasing Hormone

Keywords

  • Brattleboro rats
  • Co-localizations
  • Osmotic challenge
  • Oxytocin
  • Vasopressin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats. / Bundzikova, Jana; Pirnik, Zdeno; Zelena, D.; Mikkelsen, Jens D.; Kiss, Alexander.

In: Cellular and Molecular Neurobiology, Vol. 28, No. 8, 12.2008, p. 1033-1047.

Research output: Contribution to journalArticle

Bundzikova, Jana ; Pirnik, Zdeno ; Zelena, D. ; Mikkelsen, Jens D. ; Kiss, Alexander. / Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats. In: Cellular and Molecular Neurobiology. 2008 ; Vol. 28, No. 8. pp. 1033-1047.
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