Respiratory impedance in healthy subjects

Baseline values and bronchodilator response

Ellie Oostveen, K. Boda, Chris P M Van Der Grinten, Alan L. James, Sally Young, Hans Nieland, Z. Hantos

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Because of the minimal demand for cooperation by the subject, the forced oscillation technique is increasingly employed in routine lung function testing. However, comprehensive and device-independent values of respiratory impedance at baseline and after bronchodilation have not been established for healthy adults. The aim of this multicentre study was to collect impedance data from 4 to 26 Hz in healthy Caucasian subjects between 18 and 80 years of age. Five different devices were employed to assess baseline values and the bronchodilator response. Altogether, 368 subjects were examined. Despite adjustment for anthropometry, the impedance spectra differed in frequency dependence between the centres, and hence could not be pooled. However, resistance at all frequencies except 20 and 25 Hz, and the low-frequency (≤ 14 Hz) values of reactance did not exhibit a centre dependence. The regression equations for resistance reflected a greater height dependence in males and a greater weight dependence in both males and females than those published previously. Bronchodilation resulted in a statistically significant decrease (11%) in resistance and a 95th percentile equal to a 32% decrease in resistance at low frequency. We conclude that rigorous calibration procedures should be developed to ensure data compatibility. Furthermore, new reference equations based on different setups are recommended to replace thoseestablished with a single device.

Original languageEnglish
Pages (from-to)1513-1523
Number of pages11
JournalEuropean Respiratory Journal
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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Bronchodilator Agents
Electric Impedance
Healthy Volunteers
Equipment and Supplies
Anthropometry
Calibration
Multicenter Studies
Weights and Measures
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Respiratory impedance in healthy subjects : Baseline values and bronchodilator response. / Oostveen, Ellie; Boda, K.; Van Der Grinten, Chris P M; James, Alan L.; Young, Sally; Nieland, Hans; Hantos, Z.

In: European Respiratory Journal, Vol. 42, No. 6, 01.12.2013, p. 1513-1523.

Research output: Contribution to journalArticle

Oostveen, Ellie ; Boda, K. ; Van Der Grinten, Chris P M ; James, Alan L. ; Young, Sally ; Nieland, Hans ; Hantos, Z. / Respiratory impedance in healthy subjects : Baseline values and bronchodilator response. In: European Respiratory Journal. 2013 ; Vol. 42, No. 6. pp. 1513-1523.
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