Resolution of the flumequine intermediate 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

József Bálint, Gabriella Egri, Gábor Vass, József Schindler, Antal Gajáry, Antal Friesz, Elemér Fogassy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Racemic 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved by the N-phthaloyl derivative of the (R)-enantiomer. The enantiomeric mixture was very effectively enriched by recrystallisation from either the melt (working best for mixtures of relatively high starting enantiomeric purities) or from solution of its hydrochloride salt (giving good results when applied for mixtures of moderate to medium enantiomeric purities). Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)809-813
Number of pages5
JournalTetrahedron Asymmetry
Volume11
Issue number3
DOIs
Publication statusPublished - Feb 25 2000

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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