Resolution of enantiomers by non-conventional methods

Elemér Fogassy, Mihály Nógrádi, Emese Pálovics, József Schindler

Research output: Contribution to journalReview article

59 Citations (Scopus)


Despite unprecedented advances in enantioselective synthesis and separation techniques, large scale production of enantiopure substances, such as required by the pharmaceutical and pesticide industries, is still heavily dependent upon the separation of diastereomers obtained from the enantiomers and an optically active resolving agent. Economy of the process can be much enhanced when only a half-equivalent of the resolving agent is used. Substitution of the other half-equivalent by some achiral compound, as well as separation of the unreacted portion of the substrate from the diastereomer by various physical methods, is discussed. Methods for selecting optimal conditions of resolution and for the purification of partially resolved mixtures are also discussed.

Original languageEnglish
Pages (from-to)1555-1568
Number of pages14
Issue number10
Publication statusPublished - Jul 1 2005


  • Choice of optimal conditions
  • Half-equivalent methods
  • Resolution of enantiomers

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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