Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Dennis R. Mosier, L. Siklós, Stanley H. Appel

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalNeurology
Volume54
Issue number1
Publication statusPublished - Jan 11 2000

Fingerprint

Amyotrophic Lateral Sclerosis
Motor Neurons
Calcium
Serum
Presynaptic Terminals

Keywords

  • ALS
  • Calcium-binding proteins
  • Extraocular muscles
  • Neuromuscular junction
  • Selective vulnerability
  • Transmitter release

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera. / Mosier, Dennis R.; Siklós, L.; Appel, Stanley H.

In: Neurology, Vol. 54, No. 1, 11.01.2000, p. 252-255.

Research output: Contribution to journalArticle

Mosier, Dennis R. ; Siklós, L. ; Appel, Stanley H. / Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera. In: Neurology. 2000 ; Vol. 54, No. 1. pp. 252-255.
@article{4b9ea24ca901499782ae3643afd1fc5b,
title = "Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera",
abstract = "In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.",
keywords = "ALS, Calcium-binding proteins, Extraocular muscles, Neuromuscular junction, Selective vulnerability, Transmitter release",
author = "Mosier, {Dennis R.} and L. Sikl{\'o}s and Appel, {Stanley H.}",
year = "2000",
month = "1",
day = "11",
language = "English",
volume = "54",
pages = "252--255",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

AU - Mosier, Dennis R.

AU - Siklós, L.

AU - Appel, Stanley H.

PY - 2000/1/11

Y1 - 2000/1/11

N2 - In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

AB - In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

KW - ALS

KW - Calcium-binding proteins

KW - Extraocular muscles

KW - Neuromuscular junction

KW - Selective vulnerability

KW - Transmitter release

UR - http://www.scopus.com/inward/record.url?scp=0033971175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033971175&partnerID=8YFLogxK

M3 - Article

C2 - 10636164

AN - SCOPUS:0033971175

VL - 54

SP - 252

EP - 255

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -