A fumonizin B1 kimutatása sertés szöveteiben, nagy toxintartalmu takarmány etetését követoen

Translated title of the contribution: Residue formation of fumonisin B1 in porcine tissues after feeding diet of high toxin concentration

Kovács Melinda, Fodor Judit, Karsten Meyer, Katrin Mohr, Johann Bauer, I. Repa, Vetési Ferenc, P. Horn, Kovács Ferenc

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The residues deriving from the uptake of fumonisin B1 (FB 1) were determined in growing pigs. Fungal culture of Fusarium moniliforme was added to the diet to provide 100 mg/animal (7,5-7,6 mg/kg bw) daily FB1 intake for 5-10 days. Animals fed on the toxin containing diet became depressed, lost appetite, their feed intake decreased. Five animals died on the 5th, 6th and 8th day of the experiment. They showed severe dyspnoe, the mucous membranes showed signs of cyanosis. Six and two animals were slaughtered on the 6th and 11 th day. Among the haematological parameters, elevated red blood cell count (9,3-10,8 × 106 /μl), haemoglobin concentration (15,8-17,2 g/dl), haematocrite value (54-66%) and decreased MCH value (14,3-16,6 pg) were observed. This could presumably be due to a compensatory functioning, i.e. more intensive red blood cell and haemoglobin production. Among the clinical chemical parameters examined, the high aspartate aminotransferase activity (116-330 U/l) revealed to hepatic injury. The average total FB 1 intake in the first 5 days was 403,8 (365,8-465,8) mg, the daily toxin intake was 30,4-35,9 mg/kg bw. Generally, the determined toxin concentrations showed very large variations. No correlation between residue concentration and FB1 intake could be observed. Particularly high levels could be measured in kidney (81,6-4762,4 ng/g), liver (73,6-709,6 ng/g), lung (6,4-1144,8 ng/g), spleen (28-7975,2 ng/g) and pancreas (24-464 ng/g). Muscle and fat samples showed negligible contamination (43 and 6 ng/g, respectively). The two pigs, who survived the treatment period of eleven days showed remarkably lower concentrations of FB1 than the average. According to toxicological studies the NOEL (No Observed Effect Level) is 0,2 mg FB1/kg bw/day, TDI (Tolerable Daily Intake) calculated is 2 μg/kg bw/day, using a safety factor of 1000 (SCF, 2000). Considering the highest levels in edible tissues (liver, kidney, muscle and fat) the consumers risk through a carry-over from swine seems to be negligible. However, in single cases the impact by the ingestion of heavily contaminated organs may reach toxicological relevance.

Original languageHungarian
Pages (from-to)146-154
Number of pages9
JournalMagyar Allatorvosok Lapja
Volume126
Issue number3
Publication statusPublished - Mar 2004

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fumonisin B1
toxins
Swine
Diet
No-Observed-Adverse-Effect Level
liver
swine
hemoglobin
kidneys
diet
Toxicology
no observed adverse effect level
Liver
muscles
animals
acceptable daily intake
Hemoglobins
safety factor
Fats
erythrocyte count

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Melinda, K., Judit, F., Meyer, K., Mohr, K., Bauer, J., Repa, I., ... Ferenc, K. (2004). A fumonizin B1 kimutatása sertés szöveteiben, nagy toxintartalmu takarmány etetését követoen. Magyar Allatorvosok Lapja, 126(3), 146-154.

A fumonizin B1 kimutatása sertés szöveteiben, nagy toxintartalmu takarmány etetését követoen. / Melinda, Kovács; Judit, Fodor; Meyer, Karsten; Mohr, Katrin; Bauer, Johann; Repa, I.; Ferenc, Vetési; Horn, P.; Ferenc, Kovács.

In: Magyar Allatorvosok Lapja, Vol. 126, No. 3, 03.2004, p. 146-154.

Research output: Contribution to journalArticle

Melinda, K, Judit, F, Meyer, K, Mohr, K, Bauer, J, Repa, I, Ferenc, V, Horn, P & Ferenc, K 2004, 'A fumonizin B1 kimutatása sertés szöveteiben, nagy toxintartalmu takarmány etetését követoen', Magyar Allatorvosok Lapja, vol. 126, no. 3, pp. 146-154.
Melinda, Kovács ; Judit, Fodor ; Meyer, Karsten ; Mohr, Katrin ; Bauer, Johann ; Repa, I. ; Ferenc, Vetési ; Horn, P. ; Ferenc, Kovács. / A fumonizin B1 kimutatása sertés szöveteiben, nagy toxintartalmu takarmány etetését követoen. In: Magyar Allatorvosok Lapja. 2004 ; Vol. 126, No. 3. pp. 146-154.
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