Residual neurons in the lateral geniculate nucleus of adult cats following chronic disconnection from the cortex

M. Madarász, J. Somogyi, V. L. Silakov, J. Hámori

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26 Citations (Scopus)

Abstract

Residual neurons following chronic surgical disconnection from the cortex were studied by light and electron microscopy in the dorsal Lateral Geniculate Nucleus (LGN) of adult cats. One year after operation the volume of the decorticated LGN had shrunken to approximately half that of the control LGN. The number of nerve cells decreased at the same time, to 13-15% of the control, with relatively higher cell loss in A and A1 laminae than in lamina C. The Golgi, Golgi-EM and EM analysis of the residual neurons revealed that they contain two distinct nerve cell types. (1) 55% of all surviving neurons were identified as geniculo-cortical relay cells, while (2) 45% of the persisting nerve cells were interneurons. These data suggest that in the normal LGN of adult cat 7% (or more) of all nerve cells are local interneurons. Finally, those factors which might contribute to the unexpected survival of many relay neurons to the axotomy-caused retrograde degeneration, are considered and discussed.

Original languageEnglish
Pages (from-to)363-374
Number of pages12
JournalExperimental brain research
Volume52
Issue number3
DOIs
Publication statusPublished - Nov 1 1983

Keywords

  • Cat
  • Decortication
  • Lateral geniculate nucleus
  • Residual neurons

ASJC Scopus subject areas

  • Neuroscience(all)

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