Research on the quality of life of adult patients with cystic fibrosis in Hungary

Tímea Tóth, Erzsébet Mák, Nóra Galló, István Szabolcs

Research output: Contribution to journalArticle


Introduction: cystic fibrosis (cf) is the most common autosomal recessive metabolic disease. all symptoms associated with the gastrointestinal system have adverse effects on the nutritional status, which, in turn, is closely related to the prognosis for the patient. insufficient energy intake results in malnutrition, leading to worse respiratory function, and the early onset of comorbidities; it is accompanied with worse quality of life and a shortened lifespan. Aim: the aim of our research was to assess the quality of life and nutritional status of adult patients with cf in Hungary and to determine the correlations between nutritional status, lung function and the quality of life. in Hungary, we are the first to study the relationship between nutritional status and the quality of life in adult cf patients. Material and methods: 57 patients with cf from Hungary of both sexes were studied, all of them aged over 18. an assessment of the quality of life with a questionnaire was conducted among them. their nutritional status was measured with the bioelectrical impedance analysis. the most recently measured feV1 (forced expiratory volume in 1 second) values for the patients were analyzed. in order to assess the quality of life, the validated hungarian translation of the disease-specific cystic fibrosis Questionnaire-Revised (CFQ-R) - teen/adult version for ages 14 through adulthood - was used. Results: the nutritional status is worse in female patients than in male. undergoing lung transplantation did not have any impact on the nutritional status. however, we found significant differences in the feV1 values between the patients who underwent transplantation and those who did not. no strong correlation was found between any parameters of the nutritional status, feV1 and the domains of the quality of life. in the mean values of the quality of life domains, the highest score appeared in the eating domain, while the lowest one was found in the weight domain. we did not find any significant differences between the quality of life of male and female patients, except for the respiratory symptoms domain, where women's scores were lower. however, this result was not confirmed by feV1 data. transplant patients' quality of life was higher than non-transplant ones in almost all domains, with 6 domains where statistically significant differences were found. the transplant cf patients, however, had lower scores in the weight and body image domains. cf patients with lower bMi had lower quality of life than their peers. Muscle mass percentage did not differ between groups. feV1 showed a statistically significant correlation with six of the cfQ-R domains. Conclusions: our research is the first disease-specific assessment of the quality of life among hungarian adult patients with cf. in Hungary, we are the first to study the relationship between nutritional status and the quality of life in adult cf patients. we conclude that early dietetical interventions should be implemented to improve patients' condition and the quality of life.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalNew Medicine
Issue number2
Publication statusPublished - Jan 1 2016



  • Adult
  • Cystic fibrosis
  • Mucoviscidosis
  • Nutritional status
  • Quality of life

ASJC Scopus subject areas

  • Medicine(all)

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