Reproductive outcome after exposure to surgery under anesthesia during pregnancy

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The objective of the study was to examine the teratogenic potential of surgery under anesthesia during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. An analysis of cases with congenital abnormalities and matched healthy controls was performed. Of 35,727 pregnant women who had babies without any defects (control group), 73 (0.20%) had had operations under anesthesia. Of 20,830 pregnant women who had offspring with congenital abnormalities, 31 (0.15%) had operations with anesthesia. There was no higher rate of surgery under anesthesia in any congenital abnormality group. In addition, the case-control pair analysis did not show a significantly higher rate of surgery and anesthesia in the second and third months of gestation in any group of congenital abnormalities. A lower birth weight was found in healthy newborn infants born to mothers with surgery during pregnancy, however, it was explained by the subgroup with cervical incompetence often treated by cerclage which is of limited efficacy. Surgery under anesthesia does not appear to present teratogenic risk to the fetus.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume261
Issue number4
DOIs
Publication statusPublished - Aug 1998

Fingerprint

Anesthesia
Pregnancy
Pregnant Women
Birth Weight
Fetus
Mothers
Newborn Infant
Control Groups
Population

Keywords

  • Anesthesia in pregnant women
  • Birth weight
  • Congenital abnormalities
  • Surgery during pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Reproductive outcome after exposure to surgery under anesthesia during pregnancy. / Czeizel, E.; Pataki, T.; Rockenbauer, M.

In: Archives of Gynecology and Obstetrics, Vol. 261, No. 4, 08.1998, p. 193-199.

Research output: Contribution to journalArticle

@article{76c01b44e2f34103b8d4c0acda55a78e,
title = "Reproductive outcome after exposure to surgery under anesthesia during pregnancy",
abstract = "The objective of the study was to examine the teratogenic potential of surgery under anesthesia during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. An analysis of cases with congenital abnormalities and matched healthy controls was performed. Of 35,727 pregnant women who had babies without any defects (control group), 73 (0.20{\%}) had had operations under anesthesia. Of 20,830 pregnant women who had offspring with congenital abnormalities, 31 (0.15{\%}) had operations with anesthesia. There was no higher rate of surgery under anesthesia in any congenital abnormality group. In addition, the case-control pair analysis did not show a significantly higher rate of surgery and anesthesia in the second and third months of gestation in any group of congenital abnormalities. A lower birth weight was found in healthy newborn infants born to mothers with surgery during pregnancy, however, it was explained by the subgroup with cervical incompetence often treated by cerclage which is of limited efficacy. Surgery under anesthesia does not appear to present teratogenic risk to the fetus.",
keywords = "Anesthesia in pregnant women, Birth weight, Congenital abnormalities, Surgery during pregnancy",
author = "E. Czeizel and T. Pataki and M. Rockenbauer",
year = "1998",
month = "8",
doi = "10.1007/s004040050221",
language = "English",
volume = "261",
pages = "193--199",
journal = "Archiv fur Gynakologie",
issn = "0932-0067",
publisher = "J.F. Bergmann",
number = "4",

}

TY - JOUR

T1 - Reproductive outcome after exposure to surgery under anesthesia during pregnancy

AU - Czeizel, E.

AU - Pataki, T.

AU - Rockenbauer, M.

PY - 1998/8

Y1 - 1998/8

N2 - The objective of the study was to examine the teratogenic potential of surgery under anesthesia during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. An analysis of cases with congenital abnormalities and matched healthy controls was performed. Of 35,727 pregnant women who had babies without any defects (control group), 73 (0.20%) had had operations under anesthesia. Of 20,830 pregnant women who had offspring with congenital abnormalities, 31 (0.15%) had operations with anesthesia. There was no higher rate of surgery under anesthesia in any congenital abnormality group. In addition, the case-control pair analysis did not show a significantly higher rate of surgery and anesthesia in the second and third months of gestation in any group of congenital abnormalities. A lower birth weight was found in healthy newborn infants born to mothers with surgery during pregnancy, however, it was explained by the subgroup with cervical incompetence often treated by cerclage which is of limited efficacy. Surgery under anesthesia does not appear to present teratogenic risk to the fetus.

AB - The objective of the study was to examine the teratogenic potential of surgery under anesthesia during pregnancy in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. An analysis of cases with congenital abnormalities and matched healthy controls was performed. Of 35,727 pregnant women who had babies without any defects (control group), 73 (0.20%) had had operations under anesthesia. Of 20,830 pregnant women who had offspring with congenital abnormalities, 31 (0.15%) had operations with anesthesia. There was no higher rate of surgery under anesthesia in any congenital abnormality group. In addition, the case-control pair analysis did not show a significantly higher rate of surgery and anesthesia in the second and third months of gestation in any group of congenital abnormalities. A lower birth weight was found in healthy newborn infants born to mothers with surgery during pregnancy, however, it was explained by the subgroup with cervical incompetence often treated by cerclage which is of limited efficacy. Surgery under anesthesia does not appear to present teratogenic risk to the fetus.

KW - Anesthesia in pregnant women

KW - Birth weight

KW - Congenital abnormalities

KW - Surgery during pregnancy

UR - http://www.scopus.com/inward/record.url?scp=0031719824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031719824&partnerID=8YFLogxK

U2 - 10.1007/s004040050221

DO - 10.1007/s004040050221

M3 - Article

C2 - 9789650

AN - SCOPUS:0031719824

VL - 261

SP - 193

EP - 199

JO - Archiv fur Gynakologie

JF - Archiv fur Gynakologie

SN - 0932-0067

IS - 4

ER -