Abstract
Controversial reports have been published about the influence of sperm source and of the underlying testicular pathology on success rates of intracytoplasmic sperm injection (ICSI). In this controlled study, ICSI treatment cycles with testicular spermatozoa from men with obstructive and non-obstructive azoospermia were compared with ICSI ejaculated sperm cycles with semen parameters ≤ 5 x 106/ml and ≤ 10% progressive motility. The control cases were matched for female age, rank of trial, female basal follicle-stimulating hormone serum concentrations and close proximity to the study group's procedure. The fertilization, cleavage, pregnancy and abortion rates were similar in matched groups irrespective of the type of azoospermia. However, the implantation rate in the non-obstructive azoospermic patient group was significantly lower than that in the matched ejaculated sperm group (13.4% versus 26%, P = 0.05). On the other hand, no impairment of the implantation rate was observed in the obstructive azoospermic patient group. These data show that testicular pathology has a negative impact on reproductive performance of testicular spermatozoa, resulting in a decreased implantation potential without any apparent effect on fertilization and early preimplantation development.
| Original language | English |
|---|---|
| Pages (from-to) | 2796-2800 |
| Number of pages | 5 |
| Journal | Human Reproduction |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Azoospermia
- Fertilization
- ICSI
- Implantation
- Spermatozoa
ASJC Scopus subject areas
- Physiology
- Developmental Biology
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Reproductive capacity of spermatozoa from men with testicular failure. / Ubaldi, Filippo; Nagy, P.; Rienzi, Laura; Tesarik, Jan; Anniballo, Reno; Franco, Giorgio; Menchini-Fabris, Fabrizio; Greco, Ermanno.
In: Human Reproduction, Vol. 14, No. 11, 1999, p. 2796-2800.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reproductive capacity of spermatozoa from men with testicular failure
AU - Ubaldi, Filippo
AU - Nagy, P.
AU - Rienzi, Laura
AU - Tesarik, Jan
AU - Anniballo, Reno
AU - Franco, Giorgio
AU - Menchini-Fabris, Fabrizio
AU - Greco, Ermanno
PY - 1999
Y1 - 1999
N2 - Controversial reports have been published about the influence of sperm source and of the underlying testicular pathology on success rates of intracytoplasmic sperm injection (ICSI). In this controlled study, ICSI treatment cycles with testicular spermatozoa from men with obstructive and non-obstructive azoospermia were compared with ICSI ejaculated sperm cycles with semen parameters ≤ 5 x 106/ml and ≤ 10% progressive motility. The control cases were matched for female age, rank of trial, female basal follicle-stimulating hormone serum concentrations and close proximity to the study group's procedure. The fertilization, cleavage, pregnancy and abortion rates were similar in matched groups irrespective of the type of azoospermia. However, the implantation rate in the non-obstructive azoospermic patient group was significantly lower than that in the matched ejaculated sperm group (13.4% versus 26%, P = 0.05). On the other hand, no impairment of the implantation rate was observed in the obstructive azoospermic patient group. These data show that testicular pathology has a negative impact on reproductive performance of testicular spermatozoa, resulting in a decreased implantation potential without any apparent effect on fertilization and early preimplantation development.
AB - Controversial reports have been published about the influence of sperm source and of the underlying testicular pathology on success rates of intracytoplasmic sperm injection (ICSI). In this controlled study, ICSI treatment cycles with testicular spermatozoa from men with obstructive and non-obstructive azoospermia were compared with ICSI ejaculated sperm cycles with semen parameters ≤ 5 x 106/ml and ≤ 10% progressive motility. The control cases were matched for female age, rank of trial, female basal follicle-stimulating hormone serum concentrations and close proximity to the study group's procedure. The fertilization, cleavage, pregnancy and abortion rates were similar in matched groups irrespective of the type of azoospermia. However, the implantation rate in the non-obstructive azoospermic patient group was significantly lower than that in the matched ejaculated sperm group (13.4% versus 26%, P = 0.05). On the other hand, no impairment of the implantation rate was observed in the obstructive azoospermic patient group. These data show that testicular pathology has a negative impact on reproductive performance of testicular spermatozoa, resulting in a decreased implantation potential without any apparent effect on fertilization and early preimplantation development.
KW - Azoospermia
KW - Fertilization
KW - ICSI
KW - Implantation
KW - Spermatozoa
UR - http://www.scopus.com/inward/record.url?scp=0032709509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032709509&partnerID=8YFLogxK
U2 - 10.1093/humrep/14.11.2796
DO - 10.1093/humrep/14.11.2796
M3 - Article
C2 - 10548625
AN - SCOPUS:0032709509
VL - 14
SP - 2796
EP - 2800
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 11
ER -