Reproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes

Pedro Dorado, R. Berecz, Macarena C. Cáceres, Idilio Conzález, Adrián Llerena

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varying results. The present study was aimed at evaluating the reproducibility of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes in healthy volunteers. The study of CYP2C9 genotypes in the family of a CYP2C9*3/*3 subject is also reported. The urinary diclofenac/4′-OH diclofenac ratio was determined on two occasions within a period of 9-12 months, and was found to be correlated (r=0.83, p

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume28
Issue number3
Publication statusPublished - 2003

Fingerprint

Diclofenac
Genotype
Healthy Volunteers
Cytochrome P-450 CYP2C9

Keywords

  • CYP2C9
  • Cytochrome P450
  • Diclofenac
  • Losartan

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Reproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes. / Dorado, Pedro; Berecz, R.; Cáceres, Macarena C.; Conzález, Idilio; Llerena, Adrián.

In: European Journal of Drug Metabolism and Pharmacokinetics, Vol. 28, No. 3, 2003, p. 213-215.

Research output: Contribution to journalArticle

Dorado, Pedro ; Berecz, R. ; Cáceres, Macarena C. ; Conzález, Idilio ; Llerena, Adrián. / Reproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes. In: European Journal of Drug Metabolism and Pharmacokinetics. 2003 ; Vol. 28, No. 3. pp. 213-215.
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AU - Llerena, Adrián

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