Repopulation of Langerhans cells during wound healing in an experimental human skin/SCID mouse model

I. Juhász, Miklös Simon, Meenhard Herlyn, J. Hunyadi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The epidermal repopulation of Langerhans cells (LCs) during wound healing was examined using a human skin/severe combined immunodeficient (SCID) mouse model. The experiments were carried out after proving the human origin of keratinocytes repopulating the wound beds using the W6/32 monoclonal antibody. It was shown that CD1a- and HLA-DR-positive dendritic cells (mostly LCs) are already detectable 2 days after injury within the newly formed epithelium. In the excisional wounds investigated, neither HLA-DR nor ICAM-1 expression of human keratinocytes was observed. Our present data suggest that LC repopulation is an early event in the process of re-epithelization.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalImmunology Letters
Volume52
Issue number2-3
DOIs
Publication statusPublished - Sep 1996

Fingerprint

SCID Mice
Langerhans Cells
Wound Healing
HLA-DR Antigens
Keratinocytes
Skin
Wounds and Injuries
Intercellular Adhesion Molecule-1
Dendritic Cells
Epithelium
Monoclonal Antibodies

Keywords

  • Langerhans cell
  • SCID mouse
  • Wound healing

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Repopulation of Langerhans cells during wound healing in an experimental human skin/SCID mouse model. / Juhász, I.; Simon, Miklös; Herlyn, Meenhard; Hunyadi, J.

In: Immunology Letters, Vol. 52, No. 2-3, 09.1996, p. 125-128.

Research output: Contribution to journalArticle

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