Replication and transmission of porcine circovirus type 2 in mice

Attila Cságola, Daniel Cadar, T. Tuboly

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Little information is known about infection, replication and transmission of porcine circovirus type 2 (PCV2) in species other than swine. Two sets of animal experiments were carried out to investigate the susceptibility of mice to PCV2 and to study their possible role in maintaining and transmitting the virus. In the first experiment 14 mice were inoculated with PCV2 by the intraperitoneal route with 5 × 102 TCID50 of the PCV2-ROM strain (Cadar et al., 2007). In a second experiment 24 mice were divided into two groups (A and B); mice in Group A (n = 18) were inoculated orally with 1 × 105 TCID50 PCV2-ROM and mice in Group B (n = 6) were left uninoculated until day 12 post inoculation (p.i.), when they were mixed with Group A. The animals were sacrificed at intervals for postmortem investigation and virus genome detection by polymerase chain reaction (PCR). The PCR results indicated that PCV2 could replicate in mice infected intraperitoneally or by the oral route, and that the virus can be transmitted directly from mouse to mouse.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalActa Veterinaria Hungarica
Volume56
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Circovirus
Porcine circovirus-2
mice
Viruses
viruses
polymerase chain reaction
Polymerase Chain Reaction
Infectious Disease Transmission
animal experimentation
mouth
Swine
Genome
swine
genome

Keywords

  • Epidemiology
  • PCV2
  • PMWS
  • Reservoir

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Replication and transmission of porcine circovirus type 2 in mice. / Cságola, Attila; Cadar, Daniel; Tuboly, T.

In: Acta Veterinaria Hungarica, Vol. 56, No. 3, 2008, p. 421-427.

Research output: Contribution to journalArticle

Cságola, Attila ; Cadar, Daniel ; Tuboly, T. / Replication and transmission of porcine circovirus type 2 in mice. In: Acta Veterinaria Hungarica. 2008 ; Vol. 56, No. 3. pp. 421-427.
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