Replay and time compression of recurring spike sequences in the hippocampus

Zoltán Nádasdy, Hajime Hirase, A. Czurkó, Jozsef Csicsvari, György Buzsáki

Research output: Contribution to journalArticle

520 Citations (Scopus)

Abstract

Information in neuronal networks may be represented by the spatiotemporal patterns of spikes. Here we examined the temporal coordination of pyramidal cell spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained to run in a defined position in space (running wheel) to activate a selected group of pyramidal cells. A template-matching method and a joint probability map method were used for sequence search. Repeating spike sequences in excess of chance occurrence were examined by comparing the number of repeating sequences in the original spike trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four different shuffling procedures were used to control for the population dynamics of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies were present in both the awake and sleeping animal in excess of what might be predicted by random variations. Spike sequences observed during wheel running were 'replayed' at a faster timescale during single sharp-wave bursts of slow-wave sleep. We hypothesize that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience. Reactivation of acquired sequences may serve to consolidate information.

Original languageEnglish
Pages (from-to)9497-9507
Number of pages11
JournalJournal of Neuroscience
Volume19
Issue number21
Publication statusPublished - Nov 1 1999

Fingerprint

Hippocampus
Sleep
Pyramidal Cells
Running
Population Dynamics
Neurons

Keywords

  • θ
  • Coding
  • Decoding
  • Memory
  • Network
  • Retrieval
  • Sharp waves
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999). Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience, 19(21), 9497-9507.

Replay and time compression of recurring spike sequences in the hippocampus. / Nádasdy, Zoltán; Hirase, Hajime; Czurkó, A.; Csicsvari, Jozsef; Buzsáki, György.

In: Journal of Neuroscience, Vol. 19, No. 21, 01.11.1999, p. 9497-9507.

Research output: Contribution to journalArticle

Nádasdy, Z, Hirase, H, Czurkó, A, Csicsvari, J & Buzsáki, G 1999, 'Replay and time compression of recurring spike sequences in the hippocampus', Journal of Neuroscience, vol. 19, no. 21, pp. 9497-9507.
Nádasdy Z, Hirase H, Czurkó A, Csicsvari J, Buzsáki G. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 1999 Nov 1;19(21):9497-9507.
Nádasdy, Zoltán ; Hirase, Hajime ; Czurkó, A. ; Csicsvari, Jozsef ; Buzsáki, György. / Replay and time compression of recurring spike sequences in the hippocampus. In: Journal of Neuroscience. 1999 ; Vol. 19, No. 21. pp. 9497-9507.
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