Replacement of methicillin-resistant Staphylococcus aureus clones in Hungary over time

A 10-year surveillance study

T. Conceição, M. Aires-de-sousa, M. Füzi, A. Tóth, J. Pászti, E. Ungvári, W. B. Van Leeuwen, A. Van Belkum, H. Grundmann, H. De Lencastre

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Hungary has been increasing and is now close to 20% among invasive isolates of S. aureus . In order to understand the evolution of MRSA in Hungary, two collections of isolates were studied: 22 representatives of a collection of 238 MRSA isolates recovered between 1994 and 1998, and a collection of 299 MRSA isolates recovered between 2001 and 2004. The isolates were first characterised by pulsed-field gel electrophoresis (PFGE) and were distributed into 19 different PFGE patterns. Representatives of each pattern were further characterised by spa typing, multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCC mec ) typing. The Hungarian clone that was predominant in 1994-1998 (PFGE E, ST239-III) had almost disappeared in 2003-2004, being replaced by the Southern German clone (PFGE B, ST228-I) and the New York/Japan epidemic clone (PFGE A, ST5-II), which represented c. 85% of the 2001-2004 isolates. Thus, this study describes, for the first time, the co-dominance and extensive spread of the New York/Japan clone in a European country.

Original languageEnglish
Pages (from-to)971-979
Number of pages9
JournalClinical Microbiology and Infection
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Hungary
Pulsed Field Gel Electrophoresis
antineoplaston A10
Methicillin-Resistant Staphylococcus aureus
Clone Cells
Japan
Multilocus Sequence Typing
Staphylococcus aureus
Chromosomes

Keywords

  • Clonal evolution
  • Epidemiology
  • Hungary
  • Molecular typing
  • MRSA
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Replacement of methicillin-resistant Staphylococcus aureus clones in Hungary over time : A 10-year surveillance study. / Conceição, T.; Aires-de-sousa, M.; Füzi, M.; Tóth, A.; Pászti, J.; Ungvári, E.; Van Leeuwen, W. B.; Van Belkum, A.; Grundmann, H.; De Lencastre, H.

In: Clinical Microbiology and Infection, Vol. 13, No. 10, 10.2007, p. 971-979.

Research output: Contribution to journalArticle

Conceição, T. ; Aires-de-sousa, M. ; Füzi, M. ; Tóth, A. ; Pászti, J. ; Ungvári, E. ; Van Leeuwen, W. B. ; Van Belkum, A. ; Grundmann, H. ; De Lencastre, H. / Replacement of methicillin-resistant Staphylococcus aureus clones in Hungary over time : A 10-year surveillance study. In: Clinical Microbiology and Infection. 2007 ; Vol. 13, No. 10. pp. 971-979.
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