Repeats with variations

Accelerated evolution of the Pin2 family of proteinase inhibitors

E. Barta, Alessandro Pintar, Sándor Pongor

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The Pin2 genes encode potato type II proteinase inhibitors that act against pathogenic attack. The first examples were found only in the Solanaceae family, but, using new EST and genomic data, we have found 11 homologous genes dispersed through almost the whole range of mono- and di-cotyledonous plants. In contrast to the repetitive precursor sequences of the Solanaceae Pin2 genes, the new homologs have only a single repeat unit. The gene family appears to have evolved from a single-domain ancestral gene through a series of gene-duplication and domain-duplication steps. A number of unequal cross-over and gene conversion events could explain the current gene and domain pattern of the Solanaceae Pin2 subfamily.

Original languageEnglish
Pages (from-to)600-603
Number of pages4
JournalTrends in Genetics
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

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Peptide Hydrolases
Solanaceae
Genes
Gene Conversion
Gene Duplication
Nucleic Acid Repetitive Sequences
Expressed Sequence Tags
Solanum tuberosum

ASJC Scopus subject areas

  • Genetics

Cite this

Repeats with variations : Accelerated evolution of the Pin2 family of proteinase inhibitors. / Barta, E.; Pintar, Alessandro; Pongor, Sándor.

In: Trends in Genetics, Vol. 18, No. 12, 01.12.2002, p. 600-603.

Research output: Contribution to journalArticle

Barta, E. ; Pintar, Alessandro ; Pongor, Sándor. / Repeats with variations : Accelerated evolution of the Pin2 family of proteinase inhibitors. In: Trends in Genetics. 2002 ; Vol. 18, No. 12. pp. 600-603.
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