Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles

Sz Takács, Andrea Szabó, G. Oszlánczi, P. Pusztai, A. Sápi, Z. Kónya, A. Papp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats' cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4-5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats' internal Mn exposure determined from brain samples. The results confirmed the non-linear dose-and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.

Original languageEnglish
Pages (from-to)426-440
Number of pages15
JournalActa Biologica Hungarica
Volume63
Issue number4
DOIs
Publication statusPublished - Dec 1 2012

Fingerprint

motility
Manganese
Nanoparticles
Rats
manganese
Implanted Electrodes
Xenobiotics
xenobiotics
brain
Wistar Rats
electrode
Metals
damage
metal
Brain
Electrodes
exposure
nanoparticle
effect
dose

Keywords

  • chronic recording
  • cortical electrical activity
  • Manganese
  • open field motility
  • rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles. / Takács, Sz; Szabó, Andrea; Oszlánczi, G.; Pusztai, P.; Sápi, A.; Kónya, Z.; Papp, A.

In: Acta Biologica Hungarica, Vol. 63, No. 4, 01.12.2012, p. 426-440.

Research output: Contribution to journalArticle

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