Abstract
Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats' cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4-5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats' internal Mn exposure determined from brain samples. The results confirmed the non-linear dose-and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.
| Original language | English |
|---|---|
| Pages (from-to) | 426-440 |
| Number of pages | 15 |
| Journal | Acta Biologica Hungarica |
| Volume | 63 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 1 2012 |
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Keywords
- chronic recording
- cortical electrical activity
- Manganese
- open field motility
- rat
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Neurology
Cite this
Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles. / Takács, Sz; Szabó, Andrea; Oszlánczi, G.; Pusztai, P.; Sápi, A.; Kónya, Z.; Papp, A.
In: Acta Biologica Hungarica, Vol. 63, No. 4, 01.12.2012, p. 426-440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Repeated simultaneous cortical electrophysiological and behavioral recording in rats exposed to manganese-containing nanoparticles
AU - Takács, Sz
AU - Szabó, Andrea
AU - Oszlánczi, G.
AU - Pusztai, P.
AU - Sápi, A.
AU - Kónya, Z.
AU - Papp, A.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats' cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4-5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats' internal Mn exposure determined from brain samples. The results confirmed the non-linear dose-and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.
AB - Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats' cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4-5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats' internal Mn exposure determined from brain samples. The results confirmed the non-linear dose-and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.
KW - chronic recording
KW - cortical electrical activity
KW - Manganese
KW - open field motility
KW - rat
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UR - http://www.scopus.com/inward/citedby.url?scp=84868700803&partnerID=8YFLogxK
U2 - 10.1556/ABiol.63.2012.4.2
DO - 10.1556/ABiol.63.2012.4.2
M3 - Article
C2 - 23134600
AN - SCOPUS:84868700803
VL - 63
SP - 426
EP - 440
JO - Acta Biologica Hungarica
JF - Acta Biologica Hungarica
SN - 0236-5383
IS - 4
ER -