Repeated-dose toxicity of common ragweed on rats

Tivadar Kiss, A. Szabó, Gabor Oszlanczi, Anita Lukacs, Zoltan Tõmar, L. Tiszlavicz, Dezso Csupor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ambrosia artemisiifolia L. is an invasive species with highly allergenic pollens. Ragweed originates from North America, but it also occurs and is spreading in Europe, causing seasonal allergic rhinitis for millions of people. Recently, the herb of A. artemisiifolia has gained popularity as medicinal plant and food. The effects of its long-Term intake are unknown; there are no toxicological data to support the safe use of this plant. The aim of our study was to assess the repeated dose toxicity of A. artemisiifolia on animals. Ragweed puree was administered in low dose (500 mg/kg b. w.) and high dose (1000 mg/kg b. w.) to male Wistar rats according to 407 OECD Guidelines for the Testing of Chemicals. Clinical symptoms, various blood chemical parameters, body weight and organ weights of the rats were measured. Reduced liver function enzymes (AST, ALT), reduced triglyceride level in the low dose and increased carbamide level in the high dose group were observed. The weight of the liver relative to body weight was significantly reduced in both groups, while the brain weight relative to body weight was significantly elevated in both groups. According to our results, the repeated use of ragweed resulted in toxic effects in rats and these results question the safety of long-Term human consumption of common ragweed.

Original languageEnglish
Article numbere0176818
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Ambrosia
Toxicity
Rats
Ambrosia artemisiifolia
toxicity
Liver
rats
dosage
Body Weight
Poisons
body weight
Urea
Brain
hay fever
Animals
Triglycerides
Blood
Introduced Species
Weights and Measures
Seasonal Allergic Rhinitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kiss, T., Szabó, A., Oszlanczi, G., Lukacs, A., Tõmar, Z., Tiszlavicz, L., & Csupor, D. (2017). Repeated-dose toxicity of common ragweed on rats. PLoS One, 12(5), [e0176818]. https://doi.org/10.1371/journal.pone.0176818

Repeated-dose toxicity of common ragweed on rats. / Kiss, Tivadar; Szabó, A.; Oszlanczi, Gabor; Lukacs, Anita; Tõmar, Zoltan; Tiszlavicz, L.; Csupor, Dezso.

In: PLoS One, Vol. 12, No. 5, e0176818, 01.05.2017.

Research output: Contribution to journalArticle

Kiss, T, Szabó, A, Oszlanczi, G, Lukacs, A, Tõmar, Z, Tiszlavicz, L & Csupor, D 2017, 'Repeated-dose toxicity of common ragweed on rats', PLoS One, vol. 12, no. 5, e0176818. https://doi.org/10.1371/journal.pone.0176818
Kiss, Tivadar ; Szabó, A. ; Oszlanczi, Gabor ; Lukacs, Anita ; Tõmar, Zoltan ; Tiszlavicz, L. ; Csupor, Dezso. / Repeated-dose toxicity of common ragweed on rats. In: PLoS One. 2017 ; Vol. 12, No. 5.
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