Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis

P. Géher, Béla Gömör

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but succesfully controlled by the use of cyclosporin. Material and Methods: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wirists, and knees) developped. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccesful usc of non-steroidal antiinflammatory drugs a combination therap with cyclosporin (4mg/kg/day) and azapropazone (300mg t.i.d.) was introduced. Results: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with succes. Conclusion: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalMedical Science Monitor
Volume7
Issue number1
Publication statusPublished - 2001

Fingerprint

Ankylosing Spondylitis
Cyclosporine
Arthritis
Apazone
Spondylitis
Therapeutics
Drug Combinations
Inflammatory Bowel Diseases
Psoriasis
Foot
Knee
Anti-Inflammatory Agents
Hand
Drug Therapy

Keywords

  • Ankylosing spondylitis
  • Cyclosporin-A
  • Peripheral arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis. / Géher, P.; Gömör, Béla.

In: Medical Science Monitor, Vol. 7, No. 1, 2001, p. 105-107.

Research output: Contribution to journalArticle

@article{e3c5f83fdb7b4d2196c13993b26b0913,
title = "Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis",
abstract = "Background: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but succesfully controlled by the use of cyclosporin. Material and Methods: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wirists, and knees) developped. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccesful usc of non-steroidal antiinflammatory drugs a combination therap with cyclosporin (4mg/kg/day) and azapropazone (300mg t.i.d.) was introduced. Results: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with succes. Conclusion: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.",
keywords = "Ankylosing spondylitis, Cyclosporin-A, Peripheral arthritis",
author = "P. G{\'e}her and B{\'e}la G{\"o}m{\"o}r",
year = "2001",
language = "English",
volume = "7",
pages = "105--107",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "1",

}

TY - JOUR

T1 - Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis

AU - Géher, P.

AU - Gömör, Béla

PY - 2001

Y1 - 2001

N2 - Background: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but succesfully controlled by the use of cyclosporin. Material and Methods: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wirists, and knees) developped. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccesful usc of non-steroidal antiinflammatory drugs a combination therap with cyclosporin (4mg/kg/day) and azapropazone (300mg t.i.d.) was introduced. Results: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with succes. Conclusion: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.

AB - Background: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but succesfully controlled by the use of cyclosporin. Material and Methods: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wirists, and knees) developped. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccesful usc of non-steroidal antiinflammatory drugs a combination therap with cyclosporin (4mg/kg/day) and azapropazone (300mg t.i.d.) was introduced. Results: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with succes. Conclusion: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.

KW - Ankylosing spondylitis

KW - Cyclosporin-A

KW - Peripheral arthritis

UR - http://www.scopus.com/inward/record.url?scp=0035143971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035143971&partnerID=8YFLogxK

M3 - Article

C2 - 11208503

AN - SCOPUS:0035143971

VL - 7

SP - 105

EP - 107

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 1

ER -