Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma

B. Szende, I. Romics, K. Minik, J. Szabó, I. Torda, S. Lovász, L. Szomor, L. Tóth, M. Bély, T. Kerényi, K. Bartók, A. Végh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

BACKGROUND. Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients. METHODS. At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl2 expression were investigated in 60 prostate carcinoma patients. Antiandrogen therapy supplemented with surgical or chemical castration was administered. Serum PSA-test and needle biopsy were repeated 13-14 weeks after starting the therapy, simultaneously with determination of the apoptotic and mitotic index, Ki67, p53, and bcl2 expression. RESULTS. Forty-seven patients were alive at the end of the study, 13 patients died. Decrease in mitotic, increase in apoptotic index predicted favourable long-term response to antiandrogen therapy. Lower Ki67 and (mutant) p53 expression in the first and also in the second biopsy pointed to favourable effect of antiandrogen treatment. Since the ratio between Ki67 and apoptotic index strongly decreased in the survivors upon therapy, changes in Ki67/apoptosis ratio is recommended as a histologically detectable predictive factor, bcl2 expression did not show significant correlation with the outcome of the disease. CONCLUSIONS. Histological evaluation of mitotic and apoptotic index, Ki67, and p53 expression in repeated biopsies contributes to predicting the value of the actual treatment and may be useful to institute alterations in therapy.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalProstate
Volume49
Issue number2
DOIs
Publication statusPublished - 2001

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Therapeutic Uses
Prostate
Carcinoma
Biopsy
Androgen Antagonists
Mitotic Index
Apoptosis
Needle Biopsy
Therapeutics
Castration
Serum
Androgens
Survivors
Genes

Keywords

  • Apoptotic and mitotic index
  • bcl
  • Ki67
  • p53
  • Prostate carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma. / Szende, B.; Romics, I.; Minik, K.; Szabó, J.; Torda, I.; Lovász, S.; Szomor, L.; Tóth, L.; Bély, M.; Kerényi, T.; Bartók, K.; Végh, A.

In: Prostate, Vol. 49, No. 2, 2001, p. 93-100.

Research output: Contribution to journalArticle

Szende, B, Romics, I, Minik, K, Szabó, J, Torda, I, Lovász, S, Szomor, L, Tóth, L, Bély, M, Kerényi, T, Bartók, K & Végh, A 2001, 'Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma', Prostate, vol. 49, no. 2, pp. 93-100. https://doi.org/10.1002/pros.1122
Szende, B. ; Romics, I. ; Minik, K. ; Szabó, J. ; Torda, I. ; Lovász, S. ; Szomor, L. ; Tóth, L. ; Bély, M. ; Kerényi, T. ; Bartók, K. ; Végh, A. / Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma. In: Prostate. 2001 ; Vol. 49, No. 2. pp. 93-100.
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abstract = "BACKGROUND. Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients. METHODS. At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl2 expression were investigated in 60 prostate carcinoma patients. Antiandrogen therapy supplemented with surgical or chemical castration was administered. Serum PSA-test and needle biopsy were repeated 13-14 weeks after starting the therapy, simultaneously with determination of the apoptotic and mitotic index, Ki67, p53, and bcl2 expression. RESULTS. Forty-seven patients were alive at the end of the study, 13 patients died. Decrease in mitotic, increase in apoptotic index predicted favourable long-term response to antiandrogen therapy. Lower Ki67 and (mutant) p53 expression in the first and also in the second biopsy pointed to favourable effect of antiandrogen treatment. Since the ratio between Ki67 and apoptotic index strongly decreased in the survivors upon therapy, changes in Ki67/apoptosis ratio is recommended as a histologically detectable predictive factor, bcl2 expression did not show significant correlation with the outcome of the disease. CONCLUSIONS. Histological evaluation of mitotic and apoptotic index, Ki67, and p53 expression in repeated biopsies contributes to predicting the value of the actual treatment and may be useful to institute alterations in therapy.",
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AU - Romics, I.

AU - Minik, K.

AU - Szabó, J.

AU - Torda, I.

AU - Lovász, S.

AU - Szomor, L.

AU - Tóth, L.

AU - Bély, M.

AU - Kerényi, T.

AU - Bartók, K.

AU - Végh, A.

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N2 - BACKGROUND. Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients. METHODS. At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl2 expression were investigated in 60 prostate carcinoma patients. Antiandrogen therapy supplemented with surgical or chemical castration was administered. Serum PSA-test and needle biopsy were repeated 13-14 weeks after starting the therapy, simultaneously with determination of the apoptotic and mitotic index, Ki67, p53, and bcl2 expression. RESULTS. Forty-seven patients were alive at the end of the study, 13 patients died. Decrease in mitotic, increase in apoptotic index predicted favourable long-term response to antiandrogen therapy. Lower Ki67 and (mutant) p53 expression in the first and also in the second biopsy pointed to favourable effect of antiandrogen treatment. Since the ratio between Ki67 and apoptotic index strongly decreased in the survivors upon therapy, changes in Ki67/apoptosis ratio is recommended as a histologically detectable predictive factor, bcl2 expression did not show significant correlation with the outcome of the disease. CONCLUSIONS. Histological evaluation of mitotic and apoptotic index, Ki67, and p53 expression in repeated biopsies contributes to predicting the value of the actual treatment and may be useful to institute alterations in therapy.

AB - BACKGROUND. Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients. METHODS. At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl2 expression were investigated in 60 prostate carcinoma patients. Antiandrogen therapy supplemented with surgical or chemical castration was administered. Serum PSA-test and needle biopsy were repeated 13-14 weeks after starting the therapy, simultaneously with determination of the apoptotic and mitotic index, Ki67, p53, and bcl2 expression. RESULTS. Forty-seven patients were alive at the end of the study, 13 patients died. Decrease in mitotic, increase in apoptotic index predicted favourable long-term response to antiandrogen therapy. Lower Ki67 and (mutant) p53 expression in the first and also in the second biopsy pointed to favourable effect of antiandrogen treatment. Since the ratio between Ki67 and apoptotic index strongly decreased in the survivors upon therapy, changes in Ki67/apoptosis ratio is recommended as a histologically detectable predictive factor, bcl2 expression did not show significant correlation with the outcome of the disease. CONCLUSIONS. Histological evaluation of mitotic and apoptotic index, Ki67, and p53 expression in repeated biopsies contributes to predicting the value of the actual treatment and may be useful to institute alterations in therapy.

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