Repair of DNA damage in light sensitive human skin diseases

Irene Horkay, L. Varga, P. Tamási, S. Gundy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalArchives of Dermatological Research
Volume263
Issue number3
DOIs
Publication statusPublished - Jan 1 1978

    Fingerprint

Keywords

  • Autoradiography
  • Cutaneous porphyria
  • Excision repair DNA synthesis
  • Polymorphous light eruption
  • Semiconservative DNA replication
  • Ultraviolet light irradiation

ASJC Scopus subject areas

  • Dermatology

Cite this