Repair of DNA damage in light sensitive human skin diseases

Irene Horkay, L. Varga, P. Tamási, S. Gundy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalArchives of Dermatological Research
Volume263
Issue number3
DOIs
Publication statusPublished - Jan 1978

Fingerprint

Skin Diseases
DNA Damage
Xeroderma Pigmentosum
Light
Skin
Erythropoietic Protoporphyria
Porphyria Cutanea Tarda
Porphyrias
Ultraviolet Rays
Autoradiography
DNA Replication
DNA Repair
DNA

Keywords

  • Autoradiography
  • Cutaneous porphyria
  • Excision repair DNA synthesis
  • Polymorphous light eruption
  • Semiconservative DNA replication
  • Ultraviolet light irradiation

ASJC Scopus subject areas

  • Dermatology

Cite this

Repair of DNA damage in light sensitive human skin diseases. / Horkay, Irene; Varga, L.; Tamási, P.; Gundy, S.

In: Archives of Dermatological Research, Vol. 263, No. 3, 01.1978, p. 307-315.

Research output: Contribution to journalArticle

Horkay, Irene ; Varga, L. ; Tamási, P. ; Gundy, S. / Repair of DNA damage in light sensitive human skin diseases. In: Archives of Dermatological Research. 1978 ; Vol. 263, No. 3. pp. 307-315.
@article{f9dbdf95fac848b8897fc2577e0aa239,
title = "Repair of DNA damage in light sensitive human skin diseases",
abstract = "Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.",
keywords = "Autoradiography, Cutaneous porphyria, Excision repair DNA synthesis, Polymorphous light eruption, Semiconservative DNA replication, Ultraviolet light irradiation",
author = "Irene Horkay and L. Varga and P. Tam{\'a}si and S. Gundy",
year = "1978",
month = "1",
doi = "10.1007/BF00446947",
language = "English",
volume = "263",
pages = "307--315",
journal = "Archiv für Dermatologische Forschung",
issn = "0340-3696",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Repair of DNA damage in light sensitive human skin diseases

AU - Horkay, Irene

AU - Varga, L.

AU - Tamási, P.

AU - Gundy, S.

PY - 1978/1

Y1 - 1978/1

N2 - Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

AB - Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

KW - Autoradiography

KW - Cutaneous porphyria

KW - Excision repair DNA synthesis

KW - Polymorphous light eruption

KW - Semiconservative DNA replication

KW - Ultraviolet light irradiation

UR - http://www.scopus.com/inward/record.url?scp=0018163429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018163429&partnerID=8YFLogxK

U2 - 10.1007/BF00446947

DO - 10.1007/BF00446947

M3 - Article

VL - 263

SP - 307

EP - 315

JO - Archiv für Dermatologische Forschung

JF - Archiv für Dermatologische Forschung

SN - 0340-3696

IS - 3

ER -