Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole

L. Rosivall, J. Peti-Peterdi, Zs Rázga, A. Fintha, Cs Bodor, S. MirzaHosseini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The afferent arteriole (AA) is an important regulatory site of renal function and blood pressure. We have demonstrated endothelial fenestration and high permeability in the vicinity of renin granulated epithelioid cells in the juxtaglomerular portion of the afferent arteriole in different mammals. The permeability of fenestrated endothelium of afferent arteriole may be important in connection to various physiologic and pathophysiologic processes. We have assumed that the permeable fenestration may serve as a communication channel between the intravascular circulation and a pathway for renin secretion. Utilising the multiphoton image technique we were able to visualise the endothelial fenestration and renin granules of the in vitro microperfused AA and in vivo AA. We demonstrated that ferritin-positive, i.e., permeable portion of the afferent arteriole, under control conditions is on average 45 μm, which is about one-third to half of the total length of the afferent arteriole. The length of this portion is not constant and can change by physiologic and pharmacologic manipulation of renin formation. The permeability of the afferent arteriole is not changing only parallel with the pharmacologically stimulated renin secretion as already demonstrated in adult rats, but also with the change of renin appearance in afferent arteriole within the very first few days of life after birth. Independently from the age there is a significant correlation between the renin-positive and permeable portion of the AA. Further studies are necessary to clarify the physiological significance of afferent arteriolar permeability and its changes in the postnatal development of the kidney, as well as in correlation with activity of renin- angiotensin system.

Original languageEnglish
Pages (from-to)7-17
Number of pages11
JournalActa Physiologica Hungarica
Volume94
Issue number1-2
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Arterioles
Renin-Angiotensin System
Permeability
Renin
Kidney
Epithelioid Cells
Secretory Pathway
Ferritins
Endothelium
Mammals
Communication
Parturition
Blood Pressure

Keywords

  • Age
  • Endothelium
  • Juxtaglomerular apparatus pathology
  • Permeability
  • Renin angiotensin system

ASJC Scopus subject areas

  • Physiology

Cite this

Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole. / Rosivall, L.; Peti-Peterdi, J.; Rázga, Zs; Fintha, A.; Bodor, Cs; MirzaHosseini, S.

In: Acta Physiologica Hungarica, Vol. 94, No. 1-2, 03.2007, p. 7-17.

Research output: Contribution to journalArticle

Rosivall, L. ; Peti-Peterdi, J. ; Rázga, Zs ; Fintha, A. ; Bodor, Cs ; MirzaHosseini, S. / Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole. In: Acta Physiologica Hungarica. 2007 ; Vol. 94, No. 1-2. pp. 7-17.
@article{1bd92f96d39f4680b0122c90251a6314,
title = "Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole",
abstract = "The afferent arteriole (AA) is an important regulatory site of renal function and blood pressure. We have demonstrated endothelial fenestration and high permeability in the vicinity of renin granulated epithelioid cells in the juxtaglomerular portion of the afferent arteriole in different mammals. The permeability of fenestrated endothelium of afferent arteriole may be important in connection to various physiologic and pathophysiologic processes. We have assumed that the permeable fenestration may serve as a communication channel between the intravascular circulation and a pathway for renin secretion. Utilising the multiphoton image technique we were able to visualise the endothelial fenestration and renin granules of the in vitro microperfused AA and in vivo AA. We demonstrated that ferritin-positive, i.e., permeable portion of the afferent arteriole, under control conditions is on average 45 μm, which is about one-third to half of the total length of the afferent arteriole. The length of this portion is not constant and can change by physiologic and pharmacologic manipulation of renin formation. The permeability of the afferent arteriole is not changing only parallel with the pharmacologically stimulated renin secretion as already demonstrated in adult rats, but also with the change of renin appearance in afferent arteriole within the very first few days of life after birth. Independently from the age there is a significant correlation between the renin-positive and permeable portion of the AA. Further studies are necessary to clarify the physiological significance of afferent arteriolar permeability and its changes in the postnatal development of the kidney, as well as in correlation with activity of renin- angiotensin system.",
keywords = "Age, Endothelium, Juxtaglomerular apparatus pathology, Permeability, Renin angiotensin system",
author = "L. Rosivall and J. Peti-Peterdi and Zs R{\'a}zga and A. Fintha and Cs Bodor and S. MirzaHosseini",
year = "2007",
month = "3",
doi = "10.1556/APhysiol.94.2007.1-2.3",
language = "English",
volume = "94",
pages = "7--17",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "1-2",

}

TY - JOUR

T1 - Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole

AU - Rosivall, L.

AU - Peti-Peterdi, J.

AU - Rázga, Zs

AU - Fintha, A.

AU - Bodor, Cs

AU - MirzaHosseini, S.

PY - 2007/3

Y1 - 2007/3

N2 - The afferent arteriole (AA) is an important regulatory site of renal function and blood pressure. We have demonstrated endothelial fenestration and high permeability in the vicinity of renin granulated epithelioid cells in the juxtaglomerular portion of the afferent arteriole in different mammals. The permeability of fenestrated endothelium of afferent arteriole may be important in connection to various physiologic and pathophysiologic processes. We have assumed that the permeable fenestration may serve as a communication channel between the intravascular circulation and a pathway for renin secretion. Utilising the multiphoton image technique we were able to visualise the endothelial fenestration and renin granules of the in vitro microperfused AA and in vivo AA. We demonstrated that ferritin-positive, i.e., permeable portion of the afferent arteriole, under control conditions is on average 45 μm, which is about one-third to half of the total length of the afferent arteriole. The length of this portion is not constant and can change by physiologic and pharmacologic manipulation of renin formation. The permeability of the afferent arteriole is not changing only parallel with the pharmacologically stimulated renin secretion as already demonstrated in adult rats, but also with the change of renin appearance in afferent arteriole within the very first few days of life after birth. Independently from the age there is a significant correlation between the renin-positive and permeable portion of the AA. Further studies are necessary to clarify the physiological significance of afferent arteriolar permeability and its changes in the postnatal development of the kidney, as well as in correlation with activity of renin- angiotensin system.

AB - The afferent arteriole (AA) is an important regulatory site of renal function and blood pressure. We have demonstrated endothelial fenestration and high permeability in the vicinity of renin granulated epithelioid cells in the juxtaglomerular portion of the afferent arteriole in different mammals. The permeability of fenestrated endothelium of afferent arteriole may be important in connection to various physiologic and pathophysiologic processes. We have assumed that the permeable fenestration may serve as a communication channel between the intravascular circulation and a pathway for renin secretion. Utilising the multiphoton image technique we were able to visualise the endothelial fenestration and renin granules of the in vitro microperfused AA and in vivo AA. We demonstrated that ferritin-positive, i.e., permeable portion of the afferent arteriole, under control conditions is on average 45 μm, which is about one-third to half of the total length of the afferent arteriole. The length of this portion is not constant and can change by physiologic and pharmacologic manipulation of renin formation. The permeability of the afferent arteriole is not changing only parallel with the pharmacologically stimulated renin secretion as already demonstrated in adult rats, but also with the change of renin appearance in afferent arteriole within the very first few days of life after birth. Independently from the age there is a significant correlation between the renin-positive and permeable portion of the AA. Further studies are necessary to clarify the physiological significance of afferent arteriolar permeability and its changes in the postnatal development of the kidney, as well as in correlation with activity of renin- angiotensin system.

KW - Age

KW - Endothelium

KW - Juxtaglomerular apparatus pathology

KW - Permeability

KW - Renin angiotensin system

UR - http://www.scopus.com/inward/record.url?scp=34248142840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248142840&partnerID=8YFLogxK

U2 - 10.1556/APhysiol.94.2007.1-2.3

DO - 10.1556/APhysiol.94.2007.1-2.3

M3 - Article

C2 - 17444272

AN - SCOPUS:34248142840

VL - 94

SP - 7

EP - 17

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 1-2

ER -