Renin-angiotensin gene polymorphism in children with uremia and essential hypertension

Ferenc Papp, Aaron L. Friedman, C. Bereczki, I. Haszon, Éva Kiss, E. Endreffy, S. Túri

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The M235T polymorphism of the angiotensinogen (ANG) gene, the I/D polymorphism of the angiotensin converting enzyme (ACE) gene, and the A1166C polymorphism of the angiotensin II type 1 receptor (AT1R) gene were identified in 70 patients with end-stage renal disease [20 pediatric ESRD, aged 14.9±3.1, years blood pressure (BP) 139±14/91±13 mmHg, 50 adult ESRD , aged 48.7±18.7 years, BP 149.1±24/96.9±12 mmHg], 35 with juvenile essential hypertension (JEHT, aged 14.4±2.7 years, 24-h mean BP 135.37±7.37/72.4±7.68 mmHg), 130 adult healthy normotensive controls (aged 34.9±8.1 years, BP 117.8±8.7/78. 7±8.5 mmHg), and 20 pediatric controls (aged 13.2±1.2 years, BP 109±6.5/71±5.9 mmHg). The ACE gene polymorphism was determined by polymerase chain reaction and the ANG and AT1R gene polymorphisms by single-step LightCycler technology. The ACE gene distribution of the Hungarian controls did not differ from the results of the other Caucasian populations. In JEHT and pediatric ESRD patients, the MT genotype of ANG was more frequent than in controls (JEHT 80%, pediatric ESRD 74% versus controls 50%, P

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalPediatric Nephrology
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2003

Fingerprint

Uremia
Angiotensins
Renin
Chronic Kidney Failure
Angiotensinogen
Blood Pressure
Peptidyl-Dipeptidase A
Pediatrics
Genes
Angiotensin Type 1 Receptor
Essential Hypertension
Genotype
Technology
Polymerase Chain Reaction
Population

Keywords

  • Angiotensin converting enzyme
  • Angiotensin II type 1 receptor
  • Angiotensinogen
  • End-stage renal disease
  • Gene polymorphism
  • Juvenile essential hypertension
  • LightCycler technology

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. / Papp, Ferenc; Friedman, Aaron L.; Bereczki, C.; Haszon, I.; Kiss, Éva; Endreffy, E.; Túri, S.

In: Pediatric Nephrology, Vol. 18, No. 2, 02.2003, p. 150-154.

Research output: Contribution to journalArticle

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