Renal tubular cell necrosis and apoptosis in transplanted kidneys

E. Toronyi, R. Lord, I. D. Bowen, F. Perner, B. Szende

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Renal wedge biopsies were taken from donors' kidneys immediately at the end of cold ischaemia and 30 min after transplantation in 11 cases. Five renal grafts showed immediate and six showed delayed renal function clinically. The ratio of apoptotic and necrotic renal tubular cells and Ki67 activity was determined in both biopsies. Necrotic and apoptotic as well as proliferating renal tubular cells were seen in all samples. Both apoptotic and proliferative activity was decreased in samples taken 30 min after transplantation in cases of immediate renal function compared to the samples taken before transplantation. This phenomenon was not observed in cases of delayed renal function.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalCell Biology International
Volume25
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Necrosis
Apoptosis
Kidney
Transplantation
Biopsy
Cold Ischemia
Transplants

Keywords

  • Apoptosis
  • Ki67 activity
  • Necrosis
  • Renal transplantation
  • Renal tubular epithelium

ASJC Scopus subject areas

  • Cell Biology

Cite this

Renal tubular cell necrosis and apoptosis in transplanted kidneys. / Toronyi, E.; Lord, R.; Bowen, I. D.; Perner, F.; Szende, B.

In: Cell Biology International, Vol. 25, No. 3, 2001, p. 267-270.

Research output: Contribution to journalArticle

Toronyi, E. ; Lord, R. ; Bowen, I. D. ; Perner, F. ; Szende, B. / Renal tubular cell necrosis and apoptosis in transplanted kidneys. In: Cell Biology International. 2001 ; Vol. 25, No. 3. pp. 267-270.
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