The aim of this study was to determine whether or not there is a functional relationship between the amount of thromboxane produced and excreted by the kidney and the actual blood pressure in hypertensive patients, in the state of provoked renal counter regulation to the blood pressure reduction, induced by a direct vasodilator, sodium nitroprusside, infusion. Another purpose of the study was to examine whether the excretion rate of the urinary TXB2 had any relationship to such urinary prostanoids as PGF(2α), 6-keto PGF(1α) and plasma renin activity (PRA). Slightly hydrated essential hypertensive patients (n = 22) were infused with sodium nitroprusside (Nipride Roche) at a rate sufficient to cause a 15% reduction in diastolic blood pressure for 5 hours after a control period of 150 minutes. In the collected urine the level of TXB2, PGF(2α) and 6-keto PGF(1α) was determined by radioimmunoassay, from the plasma samples taken at the end of each period; plasma renin activity was measured by radioimmunoassay. The urinary prostanoids were used as an index of their renal production. The TXB2 excretion was significantly enhanced in the first 150 min. period of blood pressure reduction and correlated with the control blood pressure values and blood pressure values measured in the period of BP reduction. No relationship was found between the PRA and urinary excretion of TXB2, PGF(2α) and 6-keto PGF(1α).
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - Jan 1 1986|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)