Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats

G. Szénási, G. Kottra, P. Bencsath, L. Takacs

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Abstract

The effect of acute renal denervation (RD) on water (V), sodium (U(Na)V), and potassium excretion (U(K)V) from the hypertrophied and control kidney was studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx). V, U(Na)V, and U(K)V from the hypertrophied kidney were similar before and after RD or sham RD. In contrast, in SNx rats, left RD resulted in an ipsilateral increase in V (from 2.76 ± 0.39 to 5.31 ± 0.99 μl·min-1·g-1), U(Na)V (from 109 ± 36 to 857 ± 331 nmol·min-1·g-1), and U(K)V (from 144 ± 44 to 807 ± 130 nmol·min-1·g-1; P <0.05 in all cases). Moreover, renal parameters from the hypertrophied kidney, subjected to either RD or sham RD, were not different from values after RD in SNx rats (V: Nx, sham RD = 5.72 ± 1.10; Nx, RD = 5.23 ± 0.66; SNx, RD = 5.31 ± 0.99 μl·min-1·g-1; U(Na)V: Nx, sham RD = 896 ± 319; Nx, RD = 821 ± 262; SNx, RD = 857 ± 331 nmol·min-1·g-1; U(K)V: Nx, sham RD = 782 ± 127; Nx, RD = 860 ± 82; SNx, RD = 807 ± 130 nmol·min-1·g-1). In additional experiments, integrated renal nerve activity (RNA) to the kidney in Nx and SNx rats was 4.0 ± 0.3 and 10.7 ± 0.9 μV (P <0.05), respectively. The decrease in U(Na)V elicited by splanchnic nerve stimulation (10 V, 4 Hz, 1 ms) in volume-expanded rats was attenuated in hypertrophic kidneys compared with control (C = -3,019 ± 474, hypertrophied = -1,603 ± 326 nmol·min-1·g-1, P <0.05). It is concluded that both decreased RNA and attenuated effect to splanchnic nerve stimulation contribute to the lack of denervation phenomenon from hypertrophied kidneys of anesthetized rats.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume254
Issue number1
Publication statusPublished - 1988

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Sodium
Denervation
Kidney
Water
Splanchnic Nerves
Nephrectomy

ASJC Scopus subject areas

  • Physiology

Cite this

@article{ffa993c253d045ab86dcad3ca0b4a79d,
title = "Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats",
abstract = "The effect of acute renal denervation (RD) on water (V), sodium (U(Na)V), and potassium excretion (U(K)V) from the hypertrophied and control kidney was studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx). V, U(Na)V, and U(K)V from the hypertrophied kidney were similar before and after RD or sham RD. In contrast, in SNx rats, left RD resulted in an ipsilateral increase in V (from 2.76 ± 0.39 to 5.31 ± 0.99 μl·min-1·g-1), U(Na)V (from 109 ± 36 to 857 ± 331 nmol·min-1·g-1), and U(K)V (from 144 ± 44 to 807 ± 130 nmol·min-1·g-1; P <0.05 in all cases). Moreover, renal parameters from the hypertrophied kidney, subjected to either RD or sham RD, were not different from values after RD in SNx rats (V: Nx, sham RD = 5.72 ± 1.10; Nx, RD = 5.23 ± 0.66; SNx, RD = 5.31 ± 0.99 μl·min-1·g-1; U(Na)V: Nx, sham RD = 896 ± 319; Nx, RD = 821 ± 262; SNx, RD = 857 ± 331 nmol·min-1·g-1; U(K)V: Nx, sham RD = 782 ± 127; Nx, RD = 860 ± 82; SNx, RD = 807 ± 130 nmol·min-1·g-1). In additional experiments, integrated renal nerve activity (RNA) to the kidney in Nx and SNx rats was 4.0 ± 0.3 and 10.7 ± 0.9 μV (P <0.05), respectively. The decrease in U(Na)V elicited by splanchnic nerve stimulation (10 V, 4 Hz, 1 ms) in volume-expanded rats was attenuated in hypertrophic kidneys compared with control (C = -3,019 ± 474, hypertrophied = -1,603 ± 326 nmol·min-1·g-1, P <0.05). It is concluded that both decreased RNA and attenuated effect to splanchnic nerve stimulation contribute to the lack of denervation phenomenon from hypertrophied kidneys of anesthetized rats.",
author = "G. Sz{\'e}n{\'a}si and G. Kottra and P. Bencsath and L. Takacs",
year = "1988",
language = "English",
volume = "254",
journal = "American Journal of Physiology",
issn = "0363-6119",
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TY - JOUR

T1 - Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats

AU - Szénási, G.

AU - Kottra, G.

AU - Bencsath, P.

AU - Takacs, L.

PY - 1988

Y1 - 1988

N2 - The effect of acute renal denervation (RD) on water (V), sodium (U(Na)V), and potassium excretion (U(K)V) from the hypertrophied and control kidney was studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx). V, U(Na)V, and U(K)V from the hypertrophied kidney were similar before and after RD or sham RD. In contrast, in SNx rats, left RD resulted in an ipsilateral increase in V (from 2.76 ± 0.39 to 5.31 ± 0.99 μl·min-1·g-1), U(Na)V (from 109 ± 36 to 857 ± 331 nmol·min-1·g-1), and U(K)V (from 144 ± 44 to 807 ± 130 nmol·min-1·g-1; P <0.05 in all cases). Moreover, renal parameters from the hypertrophied kidney, subjected to either RD or sham RD, were not different from values after RD in SNx rats (V: Nx, sham RD = 5.72 ± 1.10; Nx, RD = 5.23 ± 0.66; SNx, RD = 5.31 ± 0.99 μl·min-1·g-1; U(Na)V: Nx, sham RD = 896 ± 319; Nx, RD = 821 ± 262; SNx, RD = 857 ± 331 nmol·min-1·g-1; U(K)V: Nx, sham RD = 782 ± 127; Nx, RD = 860 ± 82; SNx, RD = 807 ± 130 nmol·min-1·g-1). In additional experiments, integrated renal nerve activity (RNA) to the kidney in Nx and SNx rats was 4.0 ± 0.3 and 10.7 ± 0.9 μV (P <0.05), respectively. The decrease in U(Na)V elicited by splanchnic nerve stimulation (10 V, 4 Hz, 1 ms) in volume-expanded rats was attenuated in hypertrophic kidneys compared with control (C = -3,019 ± 474, hypertrophied = -1,603 ± 326 nmol·min-1·g-1, P <0.05). It is concluded that both decreased RNA and attenuated effect to splanchnic nerve stimulation contribute to the lack of denervation phenomenon from hypertrophied kidneys of anesthetized rats.

AB - The effect of acute renal denervation (RD) on water (V), sodium (U(Na)V), and potassium excretion (U(K)V) from the hypertrophied and control kidney was studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx). V, U(Na)V, and U(K)V from the hypertrophied kidney were similar before and after RD or sham RD. In contrast, in SNx rats, left RD resulted in an ipsilateral increase in V (from 2.76 ± 0.39 to 5.31 ± 0.99 μl·min-1·g-1), U(Na)V (from 109 ± 36 to 857 ± 331 nmol·min-1·g-1), and U(K)V (from 144 ± 44 to 807 ± 130 nmol·min-1·g-1; P <0.05 in all cases). Moreover, renal parameters from the hypertrophied kidney, subjected to either RD or sham RD, were not different from values after RD in SNx rats (V: Nx, sham RD = 5.72 ± 1.10; Nx, RD = 5.23 ± 0.66; SNx, RD = 5.31 ± 0.99 μl·min-1·g-1; U(Na)V: Nx, sham RD = 896 ± 319; Nx, RD = 821 ± 262; SNx, RD = 857 ± 331 nmol·min-1·g-1; U(K)V: Nx, sham RD = 782 ± 127; Nx, RD = 860 ± 82; SNx, RD = 807 ± 130 nmol·min-1·g-1). In additional experiments, integrated renal nerve activity (RNA) to the kidney in Nx and SNx rats was 4.0 ± 0.3 and 10.7 ± 0.9 μV (P <0.05), respectively. The decrease in U(Na)V elicited by splanchnic nerve stimulation (10 V, 4 Hz, 1 ms) in volume-expanded rats was attenuated in hypertrophic kidneys compared with control (C = -3,019 ± 474, hypertrophied = -1,603 ± 326 nmol·min-1·g-1, P <0.05). It is concluded that both decreased RNA and attenuated effect to splanchnic nerve stimulation contribute to the lack of denervation phenomenon from hypertrophied kidneys of anesthetized rats.

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VL - 254

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