Renal medullary antihypertensive mechanisms

W. P. Anderson, R. L. Woods, C. J. Thomas, G. Szénási, R. G. Evans

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

1. Increasing renal perfusion pressure, using an extracorporeal circuit in rabbits and dogs, causes release from the kidney of a vasodepressor substance. 2. The hypotensive response occurs in denervated kidneys, and it is not due to platelet activating factor, nitric oxide, prostanoids or suppression of renin release. 3. In the rabbit, the pressure threshold for release of the hypotensive substance appears to be slightly above normal resting pressures. 4. The source of the hypotensive substance is medullary, since the hypotensive response to increased renal perfusion pressure is abolished in dogs and rabbits whose medullae are damaged by bromoethylamine treatment. 5. The chemical nature of the hypotensive substance remains unknown. 6. Thus the renal medulla appears to possess a hypotensive hormone, released in response to elevation of renal perfusion pressure. Many aspects of the physiology and pathology of the substance and its significance in blood pressure regulation remain to be determined.

Original languageEnglish
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue number12
Publication statusPublished - 1995

Fingerprint

Antihypertensive Agents
Kidney
Pressure
Perfusion
Rabbits
Dogs
Platelet Activating Factor
Renin
Prostaglandins
Nitric Oxide
Hormones
Pathology
Blood Pressure

Keywords

  • Angiotensin II
  • Hypertension
  • Medullipin
  • Papillary necrosis
  • Renal blood flow
  • Renal medulla
  • Renin

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Anderson, W. P., Woods, R. L., Thomas, C. J., Szénási, G., & Evans, R. G. (1995). Renal medullary antihypertensive mechanisms. Clinical and Experimental Pharmacology and Physiology, 22(12).

Renal medullary antihypertensive mechanisms. / Anderson, W. P.; Woods, R. L.; Thomas, C. J.; Szénási, G.; Evans, R. G.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 22, No. 12, 1995.

Research output: Contribution to journalArticle

Anderson, WP, Woods, RL, Thomas, CJ, Szénási, G & Evans, RG 1995, 'Renal medullary antihypertensive mechanisms', Clinical and Experimental Pharmacology and Physiology, vol. 22, no. 12.
Anderson, W. P. ; Woods, R. L. ; Thomas, C. J. ; Szénási, G. ; Evans, R. G. / Renal medullary antihypertensive mechanisms. In: Clinical and Experimental Pharmacology and Physiology. 1995 ; Vol. 22, No. 12.
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