Renal functional reserve and renal hemodynamics in hypertensive patients

Abduzhappar Gaipov, Yalcin Solak, Nurlan Zhampeissov, Aliya Dzholdasbekova, Nadezhda Popova, M. Molnár, Saltanat Tuganbekova, Elmira Iskandirova

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional and anatomic integrity of nephrons. It is not known what relation between RFR and kidney Doppler parameters. We aimed to study the relation between the RFR and renal hemodynamic parameters in hypertensive patients with and without nephropathy who had normal kidney function. Twenty-four hypertensive subjects with nephropathy (HTN-n, n = 10) and hypertension without nephropathy (HTN, n = 14) were included in the study. Control group included 11 healthy subjects. Baseline GFR (GFR1) and GFR after intake of egg protein 1 mg/kg of body weight were determined (GFR2). RFR was calculated by the following formula: (GFR2-GFR1)/GFR1 × 100%. Doppler ultrasonography was performed. Arterial blood pressure (BP), body mass index (BMI), and estimated GFR were also recorded. HTN and HTN-n groups had impaired levels of RFR compared with controls (p 

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalRenal Failure
DOIs
Publication statusAccepted/In press - Jul 28 2016

Keywords

  • Doppler ultrasound
  • hypertension
  • hypertensive nephropathy
  • protein loading test
  • Renal functional reserve
  • renal resistive index

ASJC Scopus subject areas

  • Nephrology
  • Critical Care and Intensive Care Medicine

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  • Cite this

    Gaipov, A., Solak, Y., Zhampeissov, N., Dzholdasbekova, A., Popova, N., Molnár, M., Tuganbekova, S., & Iskandirova, E. (Accepted/In press). Renal functional reserve and renal hemodynamics in hypertensive patients. Renal Failure, 1-7. https://doi.org/10.1080/0886022X.2016.1214052