Renal excretion of endothelin in children

István Máttyus, L. B. Zimmerhackl, A. Schwarz, M. Brandis, M. Miltényi, T. Tulassay

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Endothelin (ET) is a peptide with profound vasoconstrictive potential. First isolated from porcine endothelial cell supernatant, it is produced also by smooth muscle, epithelial and circulating cells. Besides vasoconstriction, a wide spectrum of biological activities of ET (via activation of membrane receptors) has been described. These include regulation of other hormones and neurotransmitters, cellular growth and proliferation, bronchoconstriction, and, in the kidney, natriuresis and water diuresis. ET exerts its effects mainly in an autocrine and paracrine fashion. A high concentration of ET is found in urine, compared with plasma originating mainly from the kidney itself. In this review we focus on the role of urinary excretion of ET in children. ET excretion was determined under different physiological and pathological conditions. In premature infants and newborns, the daily excretion of ET (corrected for body surface) was higher than in older children; it was constant, and comparable to the values in healthy adults after the age of 2 years. Renal ET excretion correlated positively with urine flow in both healthy and sick children. Conditions with tubular and/or collecting duct cell damage, such as severe hypoxia, hemolytic-uremic syndrome, renal transplantation, diabetes mellitus, chronic renal failure, and contrast media cytotoxicity were characterized by elevated urinary excretion of ET. In conclusion, the renal excretion of ET is influenced by several factors, probably reflecting the intrarenal ET production. ET has a low specificity with regard to renal injury.

Original languageEnglish
Pages (from-to)513-521
Number of pages9
JournalPediatric Nephrology
Volume11
Issue number4
DOIs
Publication statusPublished - Aug 1997

Fingerprint

Endothelins
Kidney
Renal Elimination
Urine
Natriuresis
Hemolytic-Uremic Syndrome
Bronchoconstriction
Diuresis
Vasoconstriction
Premature Infants
Kidney Transplantation
Contrast Media
Chronic Kidney Failure
Smooth Muscle
Neurotransmitter Agents
Diabetes Mellitus
Swine
Endothelial Cells
Epithelial Cells
Cell Proliferation

Keywords

  • Endothelin
  • Receptors
  • Synthesis
  • Urine

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Máttyus, I., Zimmerhackl, L. B., Schwarz, A., Brandis, M., Miltényi, M., & Tulassay, T. (1997). Renal excretion of endothelin in children. Pediatric Nephrology, 11(4), 513-521. https://doi.org/10.1007/s004670050331

Renal excretion of endothelin in children. / Máttyus, István; Zimmerhackl, L. B.; Schwarz, A.; Brandis, M.; Miltényi, M.; Tulassay, T.

In: Pediatric Nephrology, Vol. 11, No. 4, 08.1997, p. 513-521.

Research output: Contribution to journalArticle

Máttyus, I, Zimmerhackl, LB, Schwarz, A, Brandis, M, Miltényi, M & Tulassay, T 1997, 'Renal excretion of endothelin in children', Pediatric Nephrology, vol. 11, no. 4, pp. 513-521. https://doi.org/10.1007/s004670050331
Máttyus I, Zimmerhackl LB, Schwarz A, Brandis M, Miltényi M, Tulassay T. Renal excretion of endothelin in children. Pediatric Nephrology. 1997 Aug;11(4):513-521. https://doi.org/10.1007/s004670050331
Máttyus, István ; Zimmerhackl, L. B. ; Schwarz, A. ; Brandis, M. ; Miltényi, M. ; Tulassay, T. / Renal excretion of endothelin in children. In: Pediatric Nephrology. 1997 ; Vol. 11, No. 4. pp. 513-521.
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