Renal cell carcinoma - xenotransplantation into immuno-suppressed mice

L. Kopper, E. Magyarosy, P. Nagy, K. Lapis, I. Számel, S. Eckhardt, S. Csata, G. Wabrosch, D. Répássy

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4 Citations (Scopus)

Abstract

21 human renal cell carcinomas (RCC) were xenotransplantcd into artificially immunosuppressed mice. 4 tumors grew successfully retaining some characteristics of the primary tumors (according to morphology and karyotype analysis), but losing metastatic capacity. One of the serially transplantable tumors (HT 40) with hyperdiploid cellular DNA content and estrogen receptor positivity failed to respond to the single maximally tolerated dose of several cytotoxic agents.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalOncology (Switzerland)
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 1 1984

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Keywords

  • Chemotherapy
  • Estrogen receptor
  • Human tumor xenografts
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kopper, L., Magyarosy, E., Nagy, P., Lapis, K., Számel, I., Eckhardt, S., Csata, S., Wabrosch, G., & Répássy, D. (1984). Renal cell carcinoma - xenotransplantation into immuno-suppressed mice. Oncology (Switzerland), 41(1), 19-24. https://doi.org/10.1159/000225784