Renal capsule-parathymic lymph node complex: A new in vivo metastatic model in rats

Gyorgy Trencsenyi, Pal Kertai, Fruzsina Bako, J. Hunyadi, T. Márián, Zoltan Hargitai, I. Pócsi, Edit Muranyi, Laszlo Hornyak, G. Bánfalvi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The ultimate cause of cancer death is, in most cases, the appearance of metastases. The aim of the present study was to contribute to animal experimental investigations of metastatic tumor development. Materials and Methods: Rat hepatocarcinoma (He/De), mesoblastic nephroma (Ne/De) cells, and in other cases tumor-bearing lymph nodes were transplanted under the renal capsule of F344 rats. Metastatic potential of tumor cells was examined by whole body autoradiography and phosphor image analysis. The organ distribution of cells was also investigated. Results: Transplanted tumor cells resulted in metastases in the parathymic lymph nodes. Implanted India ink also demonstrated connection between the lymphatic vessels of the renal capsule and the parathymic lymph nodes. The metastatic potential was independent of the primary tumor growth rate. Conclusion: The renal capsule-parathymic lymph node complex seems to be suitable for the isolated in vivo examination of metastatic development and for the detailed analysis of secondary tumors.

Original languageEnglish
Pages (from-to)2121-2126
Number of pages6
JournalAnticancer Research
Volume29
Issue number6
Publication statusPublished - Jun 2009

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Capsules
Lymph Nodes
Kidney
Neoplasms
Mesoblastic Nephroma
Neoplasm Metastasis
Lymphatic Vessels
Inbred F344 Rats
Autoradiography
Cause of Death
Growth

Keywords

  • Autoradiography
  • Hepatocarcinoma
  • Mesoblastic nephroma
  • Metastasis
  • Parathymic lymph node

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Renal capsule-parathymic lymph node complex : A new in vivo metastatic model in rats. / Trencsenyi, Gyorgy; Kertai, Pal; Bako, Fruzsina; Hunyadi, J.; Márián, T.; Hargitai, Zoltan; Pócsi, I.; Muranyi, Edit; Hornyak, Laszlo; Bánfalvi, G.

In: Anticancer Research, Vol. 29, No. 6, 06.2009, p. 2121-2126.

Research output: Contribution to journalArticle

Trencsenyi, G, Kertai, P, Bako, F, Hunyadi, J, Márián, T, Hargitai, Z, Pócsi, I, Muranyi, E, Hornyak, L & Bánfalvi, G 2009, 'Renal capsule-parathymic lymph node complex: A new in vivo metastatic model in rats', Anticancer Research, vol. 29, no. 6, pp. 2121-2126.
Trencsenyi, Gyorgy ; Kertai, Pal ; Bako, Fruzsina ; Hunyadi, J. ; Márián, T. ; Hargitai, Zoltan ; Pócsi, I. ; Muranyi, Edit ; Hornyak, Laszlo ; Bánfalvi, G. / Renal capsule-parathymic lymph node complex : A new in vivo metastatic model in rats. In: Anticancer Research. 2009 ; Vol. 29, No. 6. pp. 2121-2126.
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