The wastewaters with high solvent concentrations cannot be fed to the treatment systems. Different scenarios for handling a wastewater containing acetone and methanol to remove and/or recover organic components are investigated by rigorous simulation. The extractive and pressure swing distillation processes are optimized by genetic algorithm (GA). The different alternatives (including incineration of the wastewater) are compared on the basis of the (capital, operation, total annual) costs. The best results are obtained with the separation of the whole quantity of the wastewater into specified purity products by extractive distillation (ED). The results obtained for pressure swing distillation with heat integration remained only slightly under those of ED.