Távoli szervi kondicionálás: rövid távú hepatoprotectiv hatások patkánymodellben

Translated title of the contribution: Remote ischemic conditioning: Short-term effects on rat liver ischemic-reperfusion injury

Zoltán Czigány, Zsolt Turóczi, Orsolya Bulhardt, Viktor Hegedüs, G. Lotz, Z. Rakonczay, Zsolt Balla, László Harsányi, Attila Szijártó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Several techniques have been developed to reduce ischemic-reperfusion injury. A novel method is the remote ischemic perconditioning, applied parallel with target organ ischemia. Aim: The aim of the study was to determine the extent of liver ischemic-reperfusion injury via the application of this novel method. Methods: Male Wistar rats (n = 30, 10/group) were subjected to 60-minute partial liver ischemia and 60-minute reperfusion. Rats in the perconditioned group received conditioning treatment during the last 40 minutes of liver ischemia by infrarenal aortic clamping. Hepatic and lower limb microcirculation was monitored by laser Doppler flowmeter during reperfusion. After reperfusion, liver samples were taken for routine histological examination and redox-state assessment. Serum transaminase activities and liver tissue heat-shock protein-72 expression were measured. Results: Parameters of microcirculation showed significant (p

Original languageHungarian
Pages (from-to)1579-1587
Number of pages9
JournalOrvosi Hetilap
Volume153
Issue number40
DOIs
Publication statusPublished - Oct 1 2012

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Reperfusion Injury
Liver
Reperfusion
Ischemia
Microcirculation
HSP72 Heat-Shock Proteins
Flowmeters
Transaminases
Constriction
Oxidation-Reduction
Wistar Rats
Lower Extremity
Lasers
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Távoli szervi kondicionálás : rövid távú hepatoprotectiv hatások patkánymodellben. / Czigány, Zoltán; Turóczi, Zsolt; Bulhardt, Orsolya; Hegedüs, Viktor; Lotz, G.; Rakonczay, Z.; Balla, Zsolt; Harsányi, László; Szijártó, Attila.

In: Orvosi Hetilap, Vol. 153, No. 40, 01.10.2012, p. 1579-1587.

Research output: Contribution to journalArticle

Czigány, Z, Turóczi, Z, Bulhardt, O, Hegedüs, V, Lotz, G, Rakonczay, Z, Balla, Z, Harsányi, L & Szijártó, A 2012, 'Távoli szervi kondicionálás: rövid távú hepatoprotectiv hatások patkánymodellben', Orvosi Hetilap, vol. 153, no. 40, pp. 1579-1587. https://doi.org/10.1556/OH.2012.29469
Czigány, Zoltán ; Turóczi, Zsolt ; Bulhardt, Orsolya ; Hegedüs, Viktor ; Lotz, G. ; Rakonczay, Z. ; Balla, Zsolt ; Harsányi, László ; Szijártó, Attila. / Távoli szervi kondicionálás : rövid távú hepatoprotectiv hatások patkánymodellben. In: Orvosi Hetilap. 2012 ; Vol. 153, No. 40. pp. 1579-1587.
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