Remote astroglial response associated with synaptic degeneration results in a net increase of perisynaptic glial fibrillary acidic protein

F. Hajós, Veronika Jancsik, P. Sótonyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Remote astroglial response was evoked in the adult rat visual cortex by unilateral destruction of the corpus geniculatum laterale. Homogenates of ipsi- and contralateral (operated and control) visual cortices were analysed by immunoblotting. A peak increase in glial fibrillary acidic protein (GFAP) was observed 2 weeks after lesion which then declined but did not return to normal showing a time course similar to that of previously observed iimunohistochemical changes. Findings prove that the mechanism underlying the enhanced immunoreactivity during remote astroglial response is an up-regulation of GFAP synthesis in the astroglial processes surrounding degenerating synapses.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalActa biologica Hungarica
Volume47
Issue number1-4
Publication statusPublished - Dec 1 1996

Keywords

  • Astrocyte
  • Degeneration
  • GFAP
  • Immunoblotting
  • Rat
  • Synapse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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