Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: An OMERACT US initiative

P. Bálint, Lene Terslev, Philippe Aegerter, George Arthur Willem Bruyn, Isabelle Chary-Valckenaere, Frederique Gandjbakhch, Annamaria Iagnocco, Sandrine Jousse-Joulin, Ingrid Möller, Esperanza Naredo, Wolfgang A. Schmidt, Richard J. Wakefield, Maria Antonietta D'Agostino

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis. Methods: Eleven sonographers evaluated 40 entheses from five patients with SpA/PsA at four bilateral sites. Nine US elementary lesions were binary-scored: hypoechogenicity, thickened insertion, enthesophytes, calcifications, erosions, bone irregularities, bursitis and Doppler signal inside and around enthesis. Kappa statistics were used to evaluate reliability. Sonographers were also asked to state which lesions can be considered as inflammatory or structural and should be included in the final definition of enthesitis. Only the lesions, scored as present in at least 75% of the entheses considered as having an enthesitis, were included in the final definition. Results: The prevalence of detected lesions was quite low except for enthesophytes (55%) and bone irregularities (54%). Reliability ranged from poor to good (the lowest for thickened enthesis (kappa 0.1 (95% CI 0 to 0.7)) and the highest for enthesophytes (kappa 0.6 (95% CI 0.5 to 0.7)). When adjusted for low prevalence, kappa values increased for all lesions, with the best result observed for detecting Doppler signal at insertion (0.9) and for bursitis (0.8). The US components included in the final definition were hypoechogenicity, increased thickness at enthesis, erosions and calcifications/enthesophytes and Doppler signal at insertion. Conclusion: By using a consensus-based stepwise approach, a final reliable US score and definition of enthesitis in SpA/PsA were produced. Further studies are sought for implementing this score in clinical trials and practice.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Psoriatic Arthritis
Bursitis
Ultrasonics
Bone and Bones
Erosion
Bone
Clinical Trials
Statistics

Keywords

  • enthesitis
  • OMERACT
  • psoriatic arthritis
  • reliability
  • scoring system
  • spondyloarthritis
  • ultrasonography

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis : An OMERACT US initiative. / Bálint, P.; Terslev, Lene; Aegerter, Philippe; Bruyn, George Arthur Willem; Chary-Valckenaere, Isabelle; Gandjbakhch, Frederique; Iagnocco, Annamaria; Jousse-Joulin, Sandrine; Möller, Ingrid; Naredo, Esperanza; Schmidt, Wolfgang A.; Wakefield, Richard J.; D'Agostino, Maria Antonietta.

In: Annals of the Rheumatic Diseases, 01.01.2018.

Research output: Contribution to journalArticle

Bálint, P, Terslev, L, Aegerter, P, Bruyn, GAW, Chary-Valckenaere, I, Gandjbakhch, F, Iagnocco, A, Jousse-Joulin, S, Möller, I, Naredo, E, Schmidt, WA, Wakefield, RJ & D'Agostino, MA 2018, 'Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: An OMERACT US initiative', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2018-213609
Bálint, P. ; Terslev, Lene ; Aegerter, Philippe ; Bruyn, George Arthur Willem ; Chary-Valckenaere, Isabelle ; Gandjbakhch, Frederique ; Iagnocco, Annamaria ; Jousse-Joulin, Sandrine ; Möller, Ingrid ; Naredo, Esperanza ; Schmidt, Wolfgang A. ; Wakefield, Richard J. ; D'Agostino, Maria Antonietta. / Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis : An OMERACT US initiative. In: Annals of the Rheumatic Diseases. 2018.
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abstract = "Objectives: To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis. Methods: Eleven sonographers evaluated 40 entheses from five patients with SpA/PsA at four bilateral sites. Nine US elementary lesions were binary-scored: hypoechogenicity, thickened insertion, enthesophytes, calcifications, erosions, bone irregularities, bursitis and Doppler signal inside and around enthesis. Kappa statistics were used to evaluate reliability. Sonographers were also asked to state which lesions can be considered as inflammatory or structural and should be included in the final definition of enthesitis. Only the lesions, scored as present in at least 75{\%} of the entheses considered as having an enthesitis, were included in the final definition. Results: The prevalence of detected lesions was quite low except for enthesophytes (55{\%}) and bone irregularities (54{\%}). Reliability ranged from poor to good (the lowest for thickened enthesis (kappa 0.1 (95{\%} CI 0 to 0.7)) and the highest for enthesophytes (kappa 0.6 (95{\%} CI 0.5 to 0.7)). When adjusted for low prevalence, kappa values increased for all lesions, with the best result observed for detecting Doppler signal at insertion (0.9) and for bursitis (0.8). The US components included in the final definition were hypoechogenicity, increased thickness at enthesis, erosions and calcifications/enthesophytes and Doppler signal at insertion. Conclusion: By using a consensus-based stepwise approach, a final reliable US score and definition of enthesitis in SpA/PsA were produced. Further studies are sought for implementing this score in clinical trials and practice.",
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AU - Aegerter, Philippe

AU - Bruyn, George Arthur Willem

AU - Chary-Valckenaere, Isabelle

AU - Gandjbakhch, Frederique

AU - Iagnocco, Annamaria

AU - Jousse-Joulin, Sandrine

AU - Möller, Ingrid

AU - Naredo, Esperanza

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