A mikro-RNS-ek jelentosége daganatos betegségekben

Translated title of the contribution: Relevance of microRNA-s in neoplastic diseases

Zsófia Tömböl, Péter Szabó, Károly Rácz, Zsolt Tulassay, Péter Igaz

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

MicroRNA molecules consisting of 19-23 nucleotides influence numerous basic physiological and pathophysiological processes as endogenous mediators of RNA interference. These molecules are capable of specifically inhibiting the translation of messenger RNA molecules, but in some cases also promote the degradation of mRNA-s. Altered microRNA expression profiles were noted in several human diseases, most data, however, are known for neoplasms. Characteristic microRNA profiles are known both in solid and haematologic malignancies. MicroRNA profiles enable the distinction of benign follicular adenomas from follicular neoplasms of the thyroid. The micro-RNA expression patterns could be associated with the clinical behaviour of certain neoplasms (e.g. lung tumours and chronic lymphocytic leukemia) as well. It is possible that small molecular weight RNA-s may be used for therapeutical purposes in the future.

Original languageHungarian
Pages (from-to)1135-1141
Number of pages7
JournalOrvosi hetilap
Volume148
Issue number24
DOIs
Publication statusPublished - Jun 17 2007

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ASJC Scopus subject areas

  • Medicine(all)

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