Relevance of ICAM-1 to alcoholic liver cirrhosis

Y. Mándi, I. Nagy, L. Krenács, I. Ocsovszky, Zs Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An elevated serum concentration of soluble intercellular adhesion molecule-1 (sICAM-1) was observed in patients with alcoholic liver cirrhosis in strong correlation with the current activity of the liver disease and the history of alcohol consumption. Circulating ICAM-1 levels were significantly elevated in the sera of all of 25 patients (1,400 ± 850 ng/ml) compared with normal healthy subjects. The highest levels of sICAM-1 (2,650 ± 560 ng/ml) were measured in those patients who suffered from superimposed acute alcoholic hepatitis (SAH). Regularly drinking cirrhotic patients without SAH also exhibited significantly higher results than those who had stopped drinking. The serum ICAM-1 concentration showed a negative correlation with the duration of abstinence. No elevated sICAM-1 was found in ascitic fluid of cirrhotic patients, which tends to discount a significant intraperitoneal production of this molecule. Flow cytometric analysis revealed an increased expression of ICAM-1 molecules on peripheral blood monocytes of cirrhotic patients. Proliferating bile ducts and parenchymal cells of cirrhotic livers displayed a positive ICAM-1 immunohistochemical reaction in 3 autopsy cases. It is concluded that the elevated levels of sICAM-1 in the serum of patients with alcoholic liver diseases may provide useful diagnostic or prognostic information. However, determination of the exact source of circulating ICAM-1 in patients with alcoholic cirrhosis still demands further investigations.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalPathobiology
Volume64
Issue number1
Publication statusPublished - Jan 1996

Fingerprint

Alcoholic Liver Cirrhosis
Intercellular Adhesion Molecule-1
Liver
Alcoholic Hepatitis
Serum
Drinking
Alcoholic Liver Diseases
Molecules
Ascitic Fluid
Bile Ducts
Alcohol Drinking
Ducts
Liver Diseases
Monocytes
Autopsy
Healthy Volunteers
Blood
History
Alcohols
Fluids

Keywords

  • Adhesion molecules
  • Alcoholic liver cirrhosis
  • Flow cytometry
  • Immunohistochemical reaction
  • Soluble ICAM-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

Cite this

Mándi, Y., Nagy, I., Krenács, L., Ocsovszky, I., & Nagy, Z. (1996). Relevance of ICAM-1 to alcoholic liver cirrhosis. Pathobiology, 64(1), 46-52.

Relevance of ICAM-1 to alcoholic liver cirrhosis. / Mándi, Y.; Nagy, I.; Krenács, L.; Ocsovszky, I.; Nagy, Zs.

In: Pathobiology, Vol. 64, No. 1, 01.1996, p. 46-52.

Research output: Contribution to journalArticle

Mándi, Y, Nagy, I, Krenács, L, Ocsovszky, I & Nagy, Z 1996, 'Relevance of ICAM-1 to alcoholic liver cirrhosis', Pathobiology, vol. 64, no. 1, pp. 46-52.
Mándi Y, Nagy I, Krenács L, Ocsovszky I, Nagy Z. Relevance of ICAM-1 to alcoholic liver cirrhosis. Pathobiology. 1996 Jan;64(1):46-52.
Mándi, Y. ; Nagy, I. ; Krenács, L. ; Ocsovszky, I. ; Nagy, Zs. / Relevance of ICAM-1 to alcoholic liver cirrhosis. In: Pathobiology. 1996 ; Vol. 64, No. 1. pp. 46-52.
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