Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease

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3 Citations (Scopus)

Abstract

The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined.Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients. These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalPsychiatry research
Volume239
DOIs
Publication statusPublished - May 30 2016

Keywords

  • Antimicrobial peptides
  • Cerebrospinal fluid
  • Copy number polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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