Relevance of cytokine production to infected pancreatic necrosis.

G. Farkas, Z. Nagy, J. Márton, Y. Mándi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the role of cytokines in septic conditions following acute pancreatitis and to elaborate a new strategy in the treatment. Increased TNF and IL-6 serum levels were found in 30% of the patients (n = 40), while the IL-6 level was elevated in all of them. There was a positive correlation between the serum IL-6 and sICAM-1 levels. The in vitro TNF and IL-6 producing capacities were initially higher in the study group, but decreased on subsequent days, especially in fatal cases (n = 3). Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. The level of sICAM-1 also decreased following PTX therapy. These results suggest that cytokines produced by activated leucocytes are important in the pathogenesis of infected pancreatic necrosis, and their inhibition might be of therapeutic advantage.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

Fingerprint

Interleukin-6
Necrosis
Cytokines
Pentoxifylline
Pancreatitis
Serum
Leukocytes
Therapeutics
Tissue Donors

ASJC Scopus subject areas

  • Surgery

Cite this

Relevance of cytokine production to infected pancreatic necrosis. / Farkas, G.; Nagy, Z.; Márton, J.; Mándi, Y.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 86-88.

Research output: Contribution to journalArticle

Farkas, G, Nagy, Z, Márton, J & Mándi, Y 1997, 'Relevance of cytokine production to infected pancreatic necrosis.', Acta Chirurgica Hungarica, vol. 36, no. 1-4, pp. 86-88.
Farkas, G. ; Nagy, Z. ; Márton, J. ; Mándi, Y. / Relevance of cytokine production to infected pancreatic necrosis. In: Acta Chirurgica Hungarica. 1997 ; Vol. 36, No. 1-4. pp. 86-88.
@article{811a614a1cca4c0499bb5370aba7e06b,
title = "Relevance of cytokine production to infected pancreatic necrosis.",
abstract = "The purpose of this study was to evaluate the role of cytokines in septic conditions following acute pancreatitis and to elaborate a new strategy in the treatment. Increased TNF and IL-6 serum levels were found in 30{\%} of the patients (n = 40), while the IL-6 level was elevated in all of them. There was a positive correlation between the serum IL-6 and sICAM-1 levels. The in vitro TNF and IL-6 producing capacities were initially higher in the study group, but decreased on subsequent days, especially in fatal cases (n = 3). Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. The level of sICAM-1 also decreased following PTX therapy. These results suggest that cytokines produced by activated leucocytes are important in the pathogenesis of infected pancreatic necrosis, and their inhibition might be of therapeutic advantage.",
author = "G. Farkas and Z. Nagy and J. M{\'a}rton and Y. M{\'a}ndi",
year = "1997",
language = "English",
volume = "36",
pages = "86--88",
journal = "Magyar Sebeszet",
issn = "0025-0295",
publisher = "Ifjusagi Lapkiado Vallalat",
number = "1-4",

}

TY - JOUR

T1 - Relevance of cytokine production to infected pancreatic necrosis.

AU - Farkas, G.

AU - Nagy, Z.

AU - Márton, J.

AU - Mándi, Y.

PY - 1997

Y1 - 1997

N2 - The purpose of this study was to evaluate the role of cytokines in septic conditions following acute pancreatitis and to elaborate a new strategy in the treatment. Increased TNF and IL-6 serum levels were found in 30% of the patients (n = 40), while the IL-6 level was elevated in all of them. There was a positive correlation between the serum IL-6 and sICAM-1 levels. The in vitro TNF and IL-6 producing capacities were initially higher in the study group, but decreased on subsequent days, especially in fatal cases (n = 3). Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. The level of sICAM-1 also decreased following PTX therapy. These results suggest that cytokines produced by activated leucocytes are important in the pathogenesis of infected pancreatic necrosis, and their inhibition might be of therapeutic advantage.

AB - The purpose of this study was to evaluate the role of cytokines in septic conditions following acute pancreatitis and to elaborate a new strategy in the treatment. Increased TNF and IL-6 serum levels were found in 30% of the patients (n = 40), while the IL-6 level was elevated in all of them. There was a positive correlation between the serum IL-6 and sICAM-1 levels. The in vitro TNF and IL-6 producing capacities were initially higher in the study group, but decreased on subsequent days, especially in fatal cases (n = 3). Administration of pentoxifylline [PTX] (400 mg/day) to septic patients following necrotizing pancreatitis resulted in TNF and IL-6 production similar to that observed in control donors. The level of sICAM-1 also decreased following PTX therapy. These results suggest that cytokines produced by activated leucocytes are important in the pathogenesis of infected pancreatic necrosis, and their inhibition might be of therapeutic advantage.

UR - http://www.scopus.com/inward/record.url?scp=0031302959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031302959&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 86

EP - 88

JO - Magyar Sebeszet

JF - Magyar Sebeszet

SN - 0025-0295

IS - 1-4

ER -