Releasing factors in the circumventricular organs of the rat brain

J. S. Kizer, M. Palkóvits, M. J. Brownstein

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

With a recently developed microdissection technique, four circumventricular organs were removed from the rat brain, and their contents of LHRH and TRH were measured. The subfornical organ, the organon vasculosum lamina terminalis, the subcommissural organ, and the area postrema all contained significant quantities of both releasing factors. The concentration of LHRH in the organon vasculosum (OVLT) was 14 ng/mg protein, 58% of that found in the median eminence. The concentration of LHRH in the remaining circumventricular organs ranged from 4.2 to 10.2 ng/mg protein. The concentration of TRH in these structures, however, was considerably lower, ranging from 0.7 to 1.8 ng/mg protein. The concentrations of LHRH and TRH in the tissue immediately adjacent to the organon vasculosum were nearly 50 times and 4 times less, respectively, than the concentration of these two releasing factors within the OVLT itself.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalEndocrinology
Volume98
Issue number2
Publication statusPublished - 1976

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Gonadotropin-Releasing Hormone
Brain
Subcommissural Organ
Subfornical Organ
Area Postrema
Microdissection
Median Eminence
Proteins
Circumventricular Organs
Organum Vasculosum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Releasing factors in the circumventricular organs of the rat brain. / Kizer, J. S.; Palkóvits, M.; Brownstein, M. J.

In: Endocrinology, Vol. 98, No. 2, 1976, p. 311-317.

Research output: Contribution to journalArticle

Kizer, JS, Palkóvits, M & Brownstein, MJ 1976, 'Releasing factors in the circumventricular organs of the rat brain', Endocrinology, vol. 98, no. 2, pp. 311-317.
Kizer, J. S. ; Palkóvits, M. ; Brownstein, M. J. / Releasing factors in the circumventricular organs of the rat brain. In: Endocrinology. 1976 ; Vol. 98, No. 2. pp. 311-317.
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