Release of histamine from isolated rat hearts during reperfusion is not dependent on length of ischemic insult, or contents of histamine in cardiac tissue

G. Valen, J. Kaszaki, I. Szabo, S. Nagy, J. Vaage

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Release of histamine (H) by ischemia-reperfusion injury was investigated in isolated rat hearts (Langendorff model). The effect of 10, 15, 20, 25, 30, 40 and 60 min ischemia (n=10 each) on H in the coronary effluent and in cardiac tissue was studied after 4 min reperfusion. Release of creatine kinase and lactate dehydrogenase in the coronary effluent increased with time of ischemia. Tissue H increased from 95±10 ng/g rat heart (mean±SEM) before ischemia to max 148±10 ng/g after 20 min ischemia (p

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalAgents and Actions
Volume40
Issue number1-2
DOIs
Publication statusPublished - Sep 1993

Fingerprint

Histamine Release
Histamine
Reperfusion
Rats
Effluents
Ischemia
Tissue
Creatine Kinase
L-Lactate Dehydrogenase
Reperfusion Injury

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

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AU - Valen, G.

AU - Kaszaki, J.

AU - Szabo, I.

AU - Nagy, S.

AU - Vaage, J.

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AB - Release of histamine (H) by ischemia-reperfusion injury was investigated in isolated rat hearts (Langendorff model). The effect of 10, 15, 20, 25, 30, 40 and 60 min ischemia (n=10 each) on H in the coronary effluent and in cardiac tissue was studied after 4 min reperfusion. Release of creatine kinase and lactate dehydrogenase in the coronary effluent increased with time of ischemia. Tissue H increased from 95±10 ng/g rat heart (mean±SEM) before ischemia to max 148±10 ng/g after 20 min ischemia (p

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