Release of cationic drugs from loaded clay minerals

I. Fejér, M. Kata, I. Erös, O. Berkesi, I. Dékány

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature of the human body (37 ± 0.5°C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage, exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution rate.

Original languageEnglish
Pages (from-to)1177-1182
Number of pages6
JournalColloid and Polymer Science
Volume279
Issue number12
DOIs
Publication statusPublished - Dec 1 2001

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Keywords

  • Desorption
  • Drug intercalation
  • Montmorillonite
  • Promethazine chloride
  • X-ray diffraction measurements

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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