Release of acetylcholine from isolated human cortical slices: Inhibitory effect of norepinephrine and phenytoin

E. S. Vizi, E. Pásztor

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Abstract

The release of acetylcholine from human isolated brain cortical slices was studied. Both K excess (47.3 mm) and inhibition of Na+K+-activated ATPase by ouabain (2 × 10-5 m) significantly enhanced the release of acetylcholine. l-Norepinephrine (10-6 m) and phenytoin (10-6 m) reduced the release of acetylcholine evoked by ouabain. When the temperature was decreased to 15°C, ouabain failed to increase the release of acetylcholine, although the resting release was not affected.

Original languageEnglish
Pages (from-to)144-153
Number of pages10
JournalExperimental Neurology
Volume73
Issue number1
DOIs
Publication statusPublished - Jul 1981

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ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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