Releasable GABA in tubular epithelium of rat kidney

S. L. Erdö, E. Dobó, A. Párducz, J. R. Wolff

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Abstract

The distribution of gamma-aminobutyric acid (GABA) in the rat kidney was examined by immunocytochemical techniques. GABA-like immunoreactivity (GABA-LI) was predominantly confined to the renal tubules, including the ascending parts of the distal tubules, and the loops of Henle, the collecting tubules and ducts, and the connective parts of the convoluted tubules. In GABA-positive cortical tubules, about half of the epithelial cells were labelled. The labelled cell type showed the ultrastructural features of principal cells. Depolarizing stimulation by ouabain and high K+ concentration evoked the efflux of endogenous GABA from kidney slices. The present findings, along with previous results, suggest that GABA released from renal tubular epithelium, and transported with the urine, might be involved in the modulation of contractility in the urinary tract.

Original languageEnglish
Pages (from-to)x1-x2
JournalExperientia
Volume47
Issue number3
Publication statusPublished - Dec 1 1991

Keywords

  • Gamma-aminobutyric acid (GABA)
  • Immunocytochemistry
  • Kidney
  • Release

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Erdö, S. L., Dobó, E., Párducz, A., & Wolff, J. R. (1991). Releasable GABA in tubular epithelium of rat kidney. Experientia, 47(3), x1-x2.