Relaxation of human isolated bronchial smooth muscle - Role of prostacyclin and prostaglandin F2 a in muscle tone

I. Hutás, P. Hadházy, L. Debreczeni, E. S. Vizi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The responses of human isolated bronchial smooth muscle to electrical stimulation and to different drugs and substances were studied. Field stimulation produced an initial contraction followed by relaxation. In the presence of muscarinic receptor blockade electrical stimulation resulted primarily in relaxation which was partly due to noradrenaline and partly due to a nonadrenergic substance. Prostacyclin (10-7 to 10-6 M) relaxed and indomethacin enhanced the muscle tone. In addition it was found that indomethacin potentiated the effect of histamine. Prostacyclin was capable of relaxing the tissue which had been previously contracted by histamine or prostaglandin F2 a . It is suggested that a defect in the metabolism of prostacyclin could be an underlying cause of bronchospasm in those cases where histamine and/or prostaglandin F2 a is involved as a pathogenetic factor.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalLung
Volume159
Issue number1
DOIs
Publication statusPublished - Dec 1981

Fingerprint

Dinoprost
Epoprostenol
Histamine
Smooth Muscle
Indomethacin
Muscles
Electric Stimulation
Bronchial Spasm
Muscarinic Receptors
Norepinephrine
Pharmaceutical Preparations

Keywords

  • Bronchial muscle
  • Histamine
  • PGF
  • Prostacyclin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Relaxation of human isolated bronchial smooth muscle - Role of prostacyclin and prostaglandin F2 a in muscle tone. / Hutás, I.; Hadházy, P.; Debreczeni, L.; Vizi, E. S.

In: Lung, Vol. 159, No. 1, 12.1981, p. 153-161.

Research output: Contribution to journalArticle

Hutás, I. ; Hadházy, P. ; Debreczeni, L. ; Vizi, E. S. / Relaxation of human isolated bronchial smooth muscle - Role of prostacyclin and prostaglandin F2 a in muscle tone. In: Lung. 1981 ; Vol. 159, No. 1. pp. 153-161.
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