Relative deficiency in CpG dinucleotides is a widespread but not unique feature of Gammaherpesvirinae genomes

M. Takács, Judit Segesdi, Katalins Balog, Mária Mezei, Gábor Tóth, J. Mináróvits

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Since methylcytosine is relatively unstable, a deficiency of CpG dinucleotides and accumulation of mutations that manifest as TpG (and its complement CpA) is a diagnostic feature of higher eukaryotic DNA sequences subjected to methylation by DNA (cytosine-5) methyltransferases. Latent viral genomes may also be affected by DNA methylation in their host cells. We calculated, therefore, frequencies of dinucleotides in 20 completely sequenced herpesvirus genomes. We found a relative deficiency of CpG dinucleotides and a surplus of TpG + CpA dinucleotides in all lymphotropic gammaherpesvirus genomes except for two strains of rhesus rhadinovirus. DNAs of two strains of human herpesvirus 7, a betaherpesvirus targeting helper T cells, and equine herpesvirus 4, an alphaherpesvirus residing in the lymphoreticular system, also had a moderate CpG deficiency and TpG + CpA surplus. In contrast, most members of Alpha-, and Betaherpesvirinae subfamilies contained a relative surplus of CpG dinucleotides in their DNAs. Our data are consistent with the idea that methylated latent genomes are involved, after reactivation and productive replication, in the natural transmission cycle of most members of Gammaherpesvirinae and certain lymphotropic members of Alpha- and Betaherpesvirinae.

Original languageEnglish
Pages (from-to)349-357
Number of pages9
JournalActa Microbiologica et Immunologica Hungarica
Volume48
Issue number3-4
DOIs
Publication statusPublished - 2001

Fingerprint

Gammaherpesvirinae
Betaherpesvirinae
Genome
Equid Herpesvirus 4
DNA (Cytosine-5-)-Methyltransferase
Rhadinovirus
Human Herpesvirus 7
Viral Genome
Herpesviridae
DNA
DNA Methylation
Helper-Inducer T-Lymphocytes
Methylation

Keywords

  • CpG deficiency
  • DNA methylation
  • Epstein-Barr virus
  • Herpesvirus genomes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

Relative deficiency in CpG dinucleotides is a widespread but not unique feature of Gammaherpesvirinae genomes. / Takács, M.; Segesdi, Judit; Balog, Katalins; Mezei, Mária; Tóth, Gábor; Mináróvits, J.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 48, No. 3-4, 2001, p. 349-357.

Research output: Contribution to journalArticle

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